Receptor activation of G proteins.
Receptor activation of G proteins.
复制标题
G 蛋白的受体激活。
DOI：
10.1096/fasebj.2.13.3139484
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Johnson,GL
中科院分区：
文献类型：
--
作者：
Weiss,ER;Kelleher,DJ;Woon,CW;Soparkar,S;Osawa,S;Heasley,LE;Johnson,GL
G蛋白是一个高度保守的膜相关蛋白家族，由α，β和γ亚基组成。α亚基对每个G蛋白都是唯一的，它与国内生产总值或GTP结合。受体，如β和α肾上腺素能儿茶酚胺、毒鼠碱激动剂和视网膜光感受器视紫红质，催化Gdp与特定G蛋白的α亚单位结合。Gα·gtp调节相应的效应酶，如腺苷酸环化酶或环鸟苷酸磷酸二酯酶。G蛋白的βγ亚单位复合体是受体催化的鸟嘌呤核苷酸亚单位交换所必需的，也是α亚单位激活效应酶的衰减器。最近对受体和G蛋白一级序列的阐明使结构预测和新的实验方法得以研究受体催化的G蛋白调节特定效应系统的机制和细胞功能的控制，包括代谢、分泌和生长。-Weiss，E.R.；Kelleher，D.J.；Woon，C.W.；Soparkar，S.；Osawa，S.；Heasley，L.E.；Johnson，G.L.受体激活G蛋白.
G proteins are a highly conserved family of membrane‐associated proteins composed of α, β, and γ subunits. The α subunit, which is unique for each G protein, binds GDP or GTP. Receptors such as those for β‐ and α‐adrenergic catecholamines, muscarinic agonists, and the retinal photoreceptor rhodopsin, catalyze the exchange of GDP for GTP binding to the α subunit of a specific G protein. Gα · GTP regulates appropriate effector enzymes such as adenylyl cyclase or the cyclic GMP phosphodiesterase. The βγ‐subunit complex of G proteins is required for efficient receptor‐catalyzed a subunit guanine nucleotide exchange and also functions as an attenuator of α subunit activation of effector enzymes. Recent elucidation of both receptor and G protein primary sequence has allowed structural predictions and new experimental approaches to study the mechanism of receptor‐catalyzed G protein regulation of specific effector systems and the control of cell function including metabolism, secretion, and growth.—Weiss, E. R.; Kelleher, D. J.; Woon, C. W.; Soparkar, S.; Osawa, S.; Heasley, L. E.; Johnson, G. L. Receptor activation of G proteins.FASEB J.2: 2841‐2848; 1988.