A micro-architectural evaluation of osteoporotic human femoral heads to guide implant placement in proximal femoral fractures.
A micro-architectural evaluation of osteoporotic human femoral heads to guide implant placement in proximal femoral fractures.
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DOI：
10.3109/17453674.2013.842432
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发表时间：
2013-10
影响因子：
3.7
通讯作者：
Simpson AH
中科院分区：
文献类型：
--
作者：
Jenkins PJ;Ramaesh R;Pankaj P;Patton JT;Howie CR;Goffin JM;Merwe Av;Wallace RJ;Porter DE;Simpson AH
骨的微结构越来越被认为是骨强度的重要决定因素。骨折的成功手术稳定取决于骨强度。我们评估了骨质疏松的人股骨头的骨微结构和强度。在股骨颈骨折的关节成形术中获得的6个股骨头，在30 μm处进行显微计算机断层扫描（microCT），并推导出整个头部感兴趣体积的骨体积比（BV/TV）、骨小梁厚度、结构模型指数、连接密度和各向异性程度。另外15个股骨头接受了来自股骨头不同区域的小梁骨立方体的压缩失效应力的机械测试。最大的密度和骨小梁厚度被发现在中央核心，从内侧距延伸到骺板疤痕。该区域也与最大程度的各向异性和板状小梁的比例相关。在骨骺区，骨小梁从骨骺瘢痕放射状排列。最弱的区域在头部的顶点和周边区域。最强的区域，在头部中央。股骨头中心含有最坚固的骨小梁，骨小梁最厚、最密。顶端区域较弱。从解剖学和力学角度来看，在该中心核心内或下方实现固定的植入物可能在骨折愈合期间实现最稳定的固定。
The micro-architecture of bone has been increasingly recognized as an important determinant of bone strength. Successful operative stabilization of fractures depends on bone strength. We evaluated the osseous micro-architecture and strength of the osteoporotic human femoral head. 6 femoral heads, obtained during arthroplasty surgery for femoral neck fracture, underwent micro-computed tomography (microCT) scanning at 30 μm, and bone volume ratio (BV/TV), trabecular thickness, structural model index, connection density, and degree of anisotropy for volumes of interest throughout the head were derived. A further 15 femoral heads underwent mechanical testing of compressive failure stress of cubes of trabecular bone from different regions of the head. The greatest density and trabecular thickness was found in the central core that extended from the medial calcar to the physeal scar. This region also correlated with the greatest degree of anisotropy and proportion of plate-like trabeculae. In the epiphyseal region, the trabeculae were organized radially from the physeal scar. The weakest area was found at the apex and peripheral areas of the head. The strongest region was at the center of the head. The center of the femoral head contained the strongest trabecular bone, with the thickest, most dense trabeculae. The apical region was weaker. From an anatomical and mechanical point of view, implants that achieve fixation in or below this central core may achieve the most stable fixation during fracture healing.
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影响因子：
0.8
作者：
Massoud EI
通讯作者：
Massoud EI
影响因子：
5.3
作者：
De Bruijn, Kirstin;den Hartog, Dennis;Roukema, Gert
通讯作者：
Roukema, Gert
影响因子：
4.1
作者：
Homminga, J;McCreadie, BR;Huiskes, R
通讯作者：
Huiskes, R
DOI：
10.1016/0020-1383(95)00125-s
发表时间：
1995-11-01
影响因子：
2.5
作者：
GUNDLE, R;GARGAN, MF;SIMPSON, AHRW
通讯作者：
SIMPSON, AHRW
影响因子：
5.3
作者：
Rozental, Tamara D.;Deschamps, Laura N.;Bouxsein, Mary L.
通讯作者：
Bouxsein, Mary L.