Strategies to improve neurodevelopmental outcomes in babies at risk of neonatal hypoglycaemia.
Strategies to improve neurodevelopmental outcomes in babies at risk of neonatal hypoglycaemia.
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DOI：
10.1016/s2352-4642(20)30387-4
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发表时间：
2021-07
期刊：
影响因子：
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通讯作者：
McKinlay CJD
中科院分区：
文献类型：
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作者：
Alsweiler JM;Harris DL;Harding JE;McKinlay CJD
新生儿低血糖与不良的后期发育有关，特别是视觉运动和执行功能受损。由于新生儿低血糖在高危婴儿中很常见，而且经常没有症状，建议在出生后1-2天内对这些婴儿进行低血糖筛查，并频繁测量血糖。新生儿低血糖可以用口含葡萄糖凝胶预防和治疗，用配方奶粉和静脉注射葡萄糖治疗低血糖婴儿也很常见。然而，尚不确定筛查、预防或治疗是否能改善有新生儿低血糖风险的婴儿的长期结果。这篇叙述性综述评估了对高危婴儿进行筛查、预防和治疗以改善长期神经发育结果的最新证据。
Neonatal hypoglycaemia is associated with adverse later development, particularly visuo-motor and executive function impairment. As neonatal hypoglycaemia is common and frequently asymptomatic in at-risk babies, it is recommended that these babies are screened for hypoglycaemia in the first 1–2 days after birth with frequent blood glucose measurements. Neonatal hypoglycaemia can be prevented and treated with buccal dextrose gel, and it is also common to treat hypoglycaemic babies with formula and intravenous dextrose. However, it is uncertain if screening, prophylaxis or treatment improves long-term outcomes of babies at risk of neonatal hypoglycaemia. This narrative review assesses the latest evidence for screening, prophylaxis and treatment of babies at risk to improve long-term neurodevelopmental outcomes.