Acid-sensing ion channels: A new target for pain and CNS diseases.
Acid-sensing ion channels: A new target for pain and CNS diseases.
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发表时间：
2009-09
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通讯作者：
K. Sluka;O. C. Winter;J. Wemmie
中科院分区：
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作者：
K. Sluka;O. C. Winter;J. Wemmie
组织中的低pH可引起动物和人类的疼痛，并且是痛觉过敏的重要因素。研究还表明，酸中毒与精神和神经疾病有关。一类新兴的pH检测受体是酸敏感离子通道（ASIC）。ASIC研究的进展提高了对pH动态在生理和病理生理过程中所起作用的理解。越来越多的证据表明，用药物靶向ASIC可能为治疗中枢神经系统疼痛和疾病提供一种有效且新颖的方法。然而，针对ASIC并适合临床使用的药物的开发仍然是一个障碍。本文综述了ASIC的最新进展及其在疼痛和中枢神经系统疾病治疗中的潜力。
Low pH in tissue can evoke pain in animals and humans, and is an important factor in hyperalgesia. Research has also implicated acidosis in psychiatric and neurological diseases. One emerging class of pH-detecting receptors is that of the acid-sensing ion channels (ASICs). Advances in ASIC research have improved the understanding of the role played by pH dynamics in physiological and pathophysiological processes. Increasing evidence suggests that targeting ASICs with pharmacological agents may offer an effective and novel approach for treating pain and diseases of the CNS. However, the development of pharmaceuticals that target ASICs and are suitable for clinical use remains an obstacle. This review provides an update on ASICs and their potential for therapeutic modification in pain and CNS diseases.