IMPORTANT INFLUENCE OF RESPIRATION ON HUMAN R-R INTERVAL POWER SPECTRA IS LARGELY IGNORED
IMPORTANT INFLUENCE OF RESPIRATION ON HUMAN R-R INTERVAL POWER SPECTRA IS LARGELY IGNORED
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DOI：
10.1152/jappl.1993.75.5.2310
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发表时间：
1993-11-01
影响因子：
3.3
通讯作者：
ECKBERG, DL
中科院分区：
文献类型：
--
作者：
BROWN, TE;BEIGHTOL, LA;ECKBERG, DL
R-R间期的频域分析被广泛用于估计到人类心脏的自主神经交通的水平。由于呼吸调节自主活动，我们确定了9名健康受试者的呼吸频率和潮气量对R-R间期功率谱的影响（快速傅立叶变换法）。我们还调查了已发表的文献，以确定在这一新兴的科学探究领域的现行做法。仰卧受试者的呼吸速率为6、7.5、10、15、17.1、20和24次呼吸/分钟，标称潮气量为1，000和1，500 ml。随着呼吸频率的增加，呼吸频率和低频（0.06-0.14 Hz）的R-R间期功率显著下降。潮气量为1，500 ml时呼吸频率下的R-R间期功率显著大于1，000 ml。呼吸频率和潮气量对平均R-R间期无显著影响。我们对报告人体R-R间期功率谱的研究进行了回顾，结果显示51%的研究控制呼吸率，11%控制潮气量，11%同时控制呼吸率和潮气量。我们的分析的主要影响是，呼吸参数强烈影响低频以及呼吸频率R-R间期功率谱，这种影响在很大程度上被忽略在已发表的研究。
Frequency-domain analyses of R-R intervals are used widely to estimate levels of autonomic neural traffic to the human heart. Because respiration modulates autonomic activity, we determined for nine healthy subjects the influence of breathing frequency and tidal volume on R-R interval power spectra (fast-Fourier transform method). We also surveyed published literature to determine current practices in this burgeoning field of scientific inquiry. Supine subjects breathed at rates of 6, 7.5, 10, 15, 17.1, 20, and 24 breaths/min and with nominal tidal volumes of 1,000 and 1,500 ml. R-R interval power at respiratory and low (0.06-0.14 Hz) frequencies declined significantly as breathing frequency increased. R-R interval power at respiratory frequencies was significantly greater at a tidal volume of 1,500 than 1,000 ml. Neither breathing frequency nor tidal volume influenced average R-R intervals significantly. Our review of studies reporting human R-R interval power spectra showed that 51% of the studies controlled respiratory rate, 11% controlled tidal volume, and 11% controlled both respiratory rate and tidal volume. The major implications of our analyses are that breathing parameters strongly influence low-frequency as well as respiratory frequency R-R interval power spectra and that this influence is largely ignored in published research.