A COMPARISON OF PSYCHOLOGICAL AND PHARMACOLOGICAL TREATMENT IN SMOKING CESSATION
A COMPARISON OF PSYCHOLOGICAL AND PHARMACOLOGICAL TREATMENT IN SMOKING CESSATION
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DOI：
10.1007/bf00846161
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
FAGERSTROM, KO
中科院分区：
文献类型：
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作者：
FAGERSTROM, KO
在一家戒烟诊所，对100名连续患者进行了一项含2毫克尼古丁的戒烟口香糖的双盲试验。所有的病人都在诊所接受了常规的心理治疗。这些患者被随机分配到尼古丁口香糖（实验组）或安慰剂口香糖（对照组）。实验组戒烟后1点、3点、6点的戒断率分别为90%、76%、63%。对照组的禁欲率分别为60%、52%和45%。在所有3个随访期间，差异均在5%水平上具有显著性。当考虑到尼古丁依赖（通过标准问卷测量）时，发现实验组中71%的高尼古丁依赖吸烟者在6个月后戒烟，而安慰剂组为39%。低尼古丁依赖患者在相同的时间间隔内分别达到75%和65%。这种口香糖被患者很好地接受，并且没有严重的副作用。
A double-blind trial of a smoking-withdrawal chewing gum containing 2 mg nicotine was conducted with 100 consecutive patients in a smoking cessation clinic. All patients received the usual psychological treatment given at the clinic. The patients were randomly assigned to a nicotine gum (the experimental group) or a placebo chewing gum (control group). The abstinence rates for the experimental group at 1, 3 and 6 mo. after quitting were 90, 76 and 63%, respectively. The comparable abstinence rates for the control group were 60, 52 and 45%. The differences were significant at the 5% level at all 3 follow-up periods. When nicotine dependence, as measured by a standard questionnaire, was taken into consideration, it was found that 71% of the high-nicotine-dependent smokers in the experimental group were abstinent after 6 mo., compared to 39% in the placebo group. Low-nicotine-dependent patients achieved 75 and 65%, respectively, for the same time interval. The gum was well accepted by patients and gave no serious side effects.