Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey.
Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey.
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DOI：
10.1016/j.clinthera.2020.09.012
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发表时间：
2020-11
影响因子：
3.2
通讯作者：
International COVID-19 Parental Attitude Study (COVIPAS) Group
中科院分区：
文献类型：
--
作者：
Goldman RD;Marneni SR;Seiler M;Brown JC;Klein EJ;Cotanda CP;Gelernter R;Yan TD;Hoeffe J;Davis AL;Griffiths MA;Hall JE;Gualco G;Mater A;Manzano S;Thompson GC;Ahmed S;Ali S;Shimizu N;International COVID-19 Parental Attitude Study (COVIPAS) Group
这项研究确定了护理人员是否愿意接受针对 2019 年冠状病毒病 (COVID-19) 疫苗开发的加速监管流程的预测因素。 2020 年 3 月 26 日至 2020 年 6 月 30 日，对 6 个国家 17 个儿科急诊科 (ED) 的 2557 名儿童护理人员进行了一项国际横断面调查。护理人员被要求从 4 个选项中选择他们对拟议的 COVID-19 疫苗审批流程最同意的选项之一，此外还询问有关人口特征、急诊科就诊和对 COVID-19 的态度等问题。使用Mann-Whitney U检验来比较非正态分布的连续变量，使用独立t检验来比较正态分布的连续变量，并使用χ2或Fisher精确检验来进行分类变量的单变量分析。使用多变量逻辑回归分析来确定与护理人员接受 COVID-19 疫苗精简开发意愿相关的独立因素。 P 值 <0.05 被认为是显着的。近一半（1101/2557；43%）的护理人员表示，他们愿意接受新的 COVID-19 疫苗的不太严格的测试和研究后批准。与看护者接受加急 COVID-19 疫苗研究的意愿相关的独立因素包括孩子是否按时接种疫苗（比值比 [OR] = 1.72；95% CI，1.29–2.31）、看护者在急诊科完成调查时对自己感染了 COVID-19 的担忧（OR = 1.1；95% CI，1.05–1.16），以及如果有疫苗可用，看护者希望其孩子接种 COVID-19 疫苗的意愿（OR = 1.84；95% CI，1.54–2.21）。与父亲相比，完成调查的母亲不太可能批准疫苗开发过程的变化（OR = 0.641；95% CI，0.529–0.775）。在全球样本中，只有不到一半的护理人员愿意接受简化的 COVID-19 疫苗测试。作为提高新疫苗接受度和采用率的努力的一部分，特别是为了保护儿童，公共卫生策略和个人提供者应了解护理人员对疫苗批准的态度并适当咨询他们。一半的护理人员接受快速批准 COVID-19 疫苗的简化流程。寻求与看护者性别相关的快速批准，以及为儿童接种疫苗的意图。对自己感染 COVID-19 的担忧与倾向于加快审批相关。
This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19). An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine–approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann–Whitney U test for comparing non–normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a χ2 or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of <0.05 was considered significant. Almost half (1101/2557; 43%) of caregivers reported that they were willing to accept less rigorous testing and postresearch approval of a new COVID-19 vaccine. Independent factors associated with caregivers' willingness to accept expedited COVID-19 vaccine research included having children who were up to date on the vaccination schedule (odds ratio [OR] = 1.72; 95% CI, 1.29–2.31), caregivers' concern about having had COVID-19 themselves at the time of survey completion in the ED (OR = 1.1; 95% CI, 1.05–1.16), and caregivers' intent to have their children vaccinated against COVID-19 if a vaccine were to become available (OR = 1.84; 95% CI, 1.54–2.21). Compared with fathers, mothers completing the survey were less likely to approve of changes in the vaccine-development process (OR = 0.641; 95% CI, 0.529–0.775). Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19 vaccine testing. As a part of an effort to increase acceptance and uptake of a new vaccine, especially in order to protect children, public health strategies and individual providers should understand caregivers' attitudes toward the approval of a vaccine and consult them appropriately. Half of caregivers accept an abridged process for rapid COVID-19 vaccine approval. Seeking fast approval associated with caregiver’s gender, intent to vaccinate child. Concern about own COVID-19 infection associated with preferring expedited approval.
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影响因子：
11.8
作者：
Lennon, Diana;Jackson, Catherine;Reid, Stewart
通讯作者：
Reid, Stewart
影响因子：
6.4
作者：
Eyal, Nir;Lipsitch, Marc;Smith, Peter G.
通讯作者：
Smith, Peter G.
DOI：
10.1097/dbp.0b013e31821bd1f5
发表时间：
2011-09-01
影响因子：
2.4
作者：
Brussoni, Mariana;Olsen, Lise
通讯作者：
Olsen, Lise
影响因子：
1.7
作者：
Elliott, Sinikka;Powell, Rachel;Brenton, Joslyn
通讯作者：
Brenton, Joslyn
影响因子：
3.7
作者：
Determann D;Korfage IJ;Lambooij MS;Bliemer M;Richardus JH;Steyerberg EW;de Bekker-Grob EW
通讯作者：
de Bekker-Grob EW