CD8α+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo
CD8α+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo
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DOI：
10.4049/jimmunol.175.1.196
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发表时间：
2005-07-01
影响因子：
4.4
通讯作者：
Heath, WR
中科院分区：
文献类型：
--
作者：
Belz, GT;Shortman, K;Heath, WR
CD8 α（+）树突状细胞（DC）已被证明是主要的DC亚群，其参与引发针对多种细胞溶解病毒（包括HSV 1型、流感病毒和牛痘病毒）的MHC I类限制性CTL免疫。CD8 α（+）DCs对CTL的致敏是否仅限于溶细胞病毒，这可能为该DC亚群提供死细胞物质，或者这些DCs是否选择性地呈递细胞内Ag，尚不清楚。为了解决这个问题，我们研究了Ag呈递给非细胞溶解性病毒，淋巴细胞性脉络丛脑膜炎病毒，和细胞内细菌，单核细胞增生李斯特菌。我们发现，无论细胞内感染的类型如何，CD8 α（+）DC都是启动CD8（+）T细胞免疫的主要DC亚群。
CD8 alpha(+) dendritic cells (DCs) have been shown to be the principal DC subset involved in priming MHC class I-restricted CTL immunity to a variety of cytolytic viruses, including HSV type 1, influenza, and vaccinia virus. Whether priming of CTLs by CD8 alpha(+) DCs is limited to cytolytic viruses, which may provide dead cellular material for this DC subset, or whether these DCs selectively present intracellular Ags, is unknown. To address this question, we examined Ag presentation to a noncytolytic virus, lymphocytic choriomeningitis virus, and to an intracellular bacterium, Listeria monocytogenes. We show that regardless of the type of intracellular infection, CD8 alpha(+) DCs are the principal DC subset that initiate CD8(+) T cell immunity.