Reappraisal of effective refractory period testing.
Reappraisal of effective refractory period testing.
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重新评估有效不应期测试。
DOI：
10.1152/ajpheart.1994.267.1.h406
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Chen,PS
中科院分区：
文献类型：
--
作者：
Fan,W;Gotoh,M;McCullen,A;Karagueuzian,HS;Chen,PS
为了检验有效不应期（ERP）测试是心脏不应期的准确和可重复测量的假设，对4只猪和12只犬进行了研究。我们将常规ERP定义为与非夺获相关的最长S1-S2间期，将三重ERP定义为由上下算法确定的三个ERP值的平均值。我们还确定了测试多个S1-S2间期后未夺获的概率曲线。结果表明，与0和100%未捕获概率相关的耦合间隔之间的差异，猪为13 +/- 1（范围12-16）ms，狗为9 +/- 2（范围4-12）ms。常规和三次ERP分别与71 +/- 20%（范围26-100%）和60 +/- 21%（范围12-100%）的非夺获概率相关。我们得出结论，ERP是一个概率函数。因此，单个ERP测定不能用作心脏不应期的准确和可重现测量，除非其用于检测猪中超过16 ms或犬中超过12 ms的ERP潜在差异。如果要检测到ERP中的较小差异，则需要确定概率函数曲线。
To test the hypothesis that effective refractory period (ERP) testing is an accurate and reproducible measure of the cardiac refractory period, 4 pigs and 12 dogs were studied. We define the conventional ERP as the longest S1–S2 interval associated with noncapture and the triplicate ERP as the average of three ERP values determined by the up-down algorithm. We also determined the probability curve for noncapture after testing multiple S1–S2 intervals. The results showed that the difference between the coupling intervals associated with a 0 and a 100% probability of noncapture was 13 +/- 1 (range 12–16) ms for pigs and 9 +/- 2 (range 4–12) ms for dogs. The conventional and the triplicate ERP were associated with a 71 +/- 20% (range 26–100%) and a 60 +/- 21% (range 12–100%) probability of noncapture, respectively. We conclude that the ERP is a probability function. Therefore a single ERP determination cannot be used as an accurate and reproducible measure of cardiac refractory period unless it is used to detect potential differences in ERP that exceed 16 ms in pigs or 12 ms in dogs. A probability function curve determination will be needed if smaller differences in the ERP are to be detected.