Physiological and molecular mechanisms of lymphocyte homing.
Physiological and molecular mechanisms of lymphocyte homing.
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DOI：
10.1146/annurev.iy.10.040192.003021
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发表时间：
1992
影响因子：
29.7
通讯作者：
L. Picker;E. Butcher
中科院分区：
文献类型：
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作者：
L. Picker;E. Butcher
淋巴系统在体内功能上分为独立的初级、次级和三级淋巴器官。初级淋巴组织--骨髓和胸腺--负责产生成熟的“处女”淋巴细胞。次级淋巴组织--淋巴结、脾和肠相关淋巴组织--专门用于抗原的积累和呈递给原始和记忆淋巴细胞亚群。身体组织的其余部分可以被认为是“三级”淋巴组织，因为它们通常仅含有少量淋巴样成分，但在炎症的情况下可以被诱导以募集主要记忆淋巴细胞的独特亚群。每个淋巴组织进一步细分为离散的微环境，每个微环境的特征在于淋巴细胞亚群和基质细胞的不同互补。淋巴细胞归巢包括淋巴细胞寻找并定位于特定组织和其中的特定微环境的生理过程。归巢机制在维持这些专门的微环境中起着重要作用，并且对于有效免疫监视所需的幼稚和记忆淋巴细胞群体的分散和靶向至关重要。在这里，我们提供了一个简要的概述，认为控制淋巴细胞群体在体内归巢的机制，特别是专注于参与淋巴细胞内皮细胞识别和淋巴细胞群体的选择性外渗到二级和三级淋巴组织中的粘附相互作用。
The lymphoid system is functionally compartmentalized in vivo into discrete primary, secondary, and tertiary lymphoid organs. Primary lymphoid tissues--the bone marrow and thymus--are responsible for the production of mature "virgin" lymphocytes. Secondary lymphoid tissues--lymph nodes, the spleen, and gut-associated lymphoid tissues--are specialized for the accumulation and presentation of antigen to both virgin and memory lymphocyte subsets. The remainder of the body's tissues may be considered "tertiary" lymphoid tissues, in that they normally contain only a few lymphoid elements, but in the setting of inflammation can be induced to recruit unique subsets of primarily memory lymphocytes. Each lymphoid tissue is further subdivided into discrete microenvironments, each characterized by a distinct complement of lymphocyte subsets and stromal cells. Lymphocyte homing comprises the physiologic processes by which lymphocytes seek out and localize to particular tissues and to specific microenvironments therein. Homing mechanisms play a major role in the maintenance of these specialized microenvironments and are critical for the dispersal and targeting of naive and memory lymphocyte populations that are required for effective immune surveillance. Here, we provide a brief overview of mechanisms thought to control the homing of lymphocyte populations in vivo, focusing in particular on the adhesive interactions involved in lymphocyte-endothelial cell recognition and in the selective extravasation of lymphocyte populations into secondary and tertiary lymphoid tissues.