SPREAD OF PLASMID-MEDIATED NOURSEOTHRICIN RESISTANCE DUE TO ANTIBIOTIC USE IN ANIMAL HUSBANDRY
SPREAD OF PLASMID-MEDIATED NOURSEOTHRICIN RESISTANCE DUE TO ANTIBIOTIC USE IN ANIMAL HUSBANDRY
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DOI：
10.1002/jobm.3620260806
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发表时间：
1986-01-01
影响因子：
3.1
通讯作者：
WITTE, W
中科院分区：
文献类型：
--
作者：
HUMMEL, R;TSCHAPE, H;WITTE, W
在畜牧业中使用链丝菌素抗生素诺尔丝菌素促进生长后，在诺尔丝菌素喂养的猪、养猪场员工及其家庭成员的大肠杆菌中观察到了质粒传播的链丝菌素耐药性。 Moreover, streptothricin resistance plasmids also occurred in E. coli of man without any contact to pig farms (gut flora and even urinary tract infections).然而，这些人生活在诺尔丝菌素用于猪的地区的村庄和城镇。在猪大肠杆菌和人大肠杆菌中都发现了属于不同不相容组的类似链丝菌素抗性质粒。由于在人类中没有观察到对治疗所必需的药物的共选择，诺尔丝菌素在畜牧业中的应用对人类医学还没有临床意义。尽管如此，这个问题仍在进一步调查中。
After using of the streptothricin antibiotic nourseothricin in animal husbandry for growth promotion, plasmid-borne resistance to streptothricin could be observed in Escherichia coli from nourseothricin fed pigs, from employees in pig farms and from their family members. Moreover, streptothricin resistance plasmids also occurred in E. coli of man without any contact to pig farms (gut flora and even urinary tract infections). However, these individuals live in villages and towns of the territory where nourseothricin was applied to pigs. Similar streptothricin resistance plasmids belonging to different incompatibility groups were found in both E. coli from pigs and E. coli from human beings. As no coselection of resistance to drugs indispensable for therapeutic use in man was observed, the application of nourseothricin in animal husbandry has no clinical implication for human medicine yet. Nevertheless, this problem remains under further investigation.