Evaluating the physiological significance of respiratory sinus arrhythmia: looking beyond ventilation-perfusion efficiency
Evaluating the physiological significance of respiratory sinus arrhythmia: looking beyond ventilation-perfusion efficiency
复制标题
DOI：
10.1113/jphysiol.2011.222422
复制
发表时间：
2012-04-01
影响因子：
5.5
通讯作者：
Paton, J. F. R.
中科院分区：
文献类型：
--
作者：
Ben-Tal, A.;Shamailov, S. S.;Paton, J. F. R.
呼吸性窦性心律不齐（RSA）是心率随呼吸的变化：心率在吸气时增加，呼气时降低。RSA见于许多物种，包括人类，在年轻和健康的时候最强。RSA的丧失与心源性死亡有关;然而，RSA的功能目前尚不清楚。之前提出的一个假设是RSA允许肺和血液之间更有效的气体交换。我们的理论研究并不支持这一假设。相反，提出了一个新的假设，并使用计算工具进行了测试，即RSA可以帮助心脏减少工作，同时保持健康的血气水平。当然，这个新的假设需要通过实验和更复杂的数学模型进行进一步的测试，但是如果正确的话，它可以解释为什么在心血管疾病患者中人工诱导RSA可以改善他们的健康。
Key points Respiratory sinus arrhythmia (RSA) is the variation of heart rate with breathing: heart rate increases during inspiration and decreases during expiration. RSA is seen in many species including humans where it is strongest in the young and fit. The loss of RSA has been linked with cardiac mortality; however, the function of RSA is presently unknown. One hypothesis proposed previously is that RSA allows for more efficient gas exchange between the lungs and the blood. Our theoretical study does not support this hypothesis. Instead, a new hypothesis is proposed and tested using computational tools that RSA helps the heart do less work while maintaining healthy levels of blood gases. Of course, this new hypothesis needs to be further tested both experimentally and by using more sophisticated mathematical models, but if correct, it could explain why inducing RSA artificially in patients with cardiovascular disease improves their health.