What is the most relevant standard of success in assisted reproduction? Is BESST (birth emphasizing a successful singleton at term) truly the best?
What is the most relevant standard of success in assisted reproduction? Is BESST (birth emphasizing a successful singleton at term) truly the best?
复制标题
辅助生殖成功的最相关标准是什么？
作者：
G. Griesinger;K. Dafopoulos;A. Schultze;R. Felberbaum;K. Diedrich
在辅助生殖技术（ART）后，对最相关的结果参数的定义存在很大的差异，没有达成共识。描述性报告，如来自国家抗逆转录病毒疗法规划成功情况登记处的年度统计数据，应以每开始一次卵巢刺激的活产数来说明治疗成功情况，因为这对患者和医生都是最相关的信息。解决对多胎妊娠率高的关切，在大型方案和国家审计中重新衡量抗逆转录病毒治疗的结果，活产，除了施加任何法律限制外，可能会引发全球对选择性单胚胎移植的态度改变。对于临床研究，结果测量将取决于所检验的假设，研究者应该自由选择适当的主要结果测量。
There is much variability and no consensus on the definition of the most relevant outcome parameter after assisted reproduction technology (ART). Descriptive reports, such as annual statistics from national registries on the success of ART programmes, should present treatment success in terms of live birth per ovarian stimulation started, as this is the most relevant information for patients and doctors alike. Addressing concerns about the high rate of multiple pregnancies, rescaling the outcome of ART in large programmes and national audits to the singleton, live birth, might trigger a global change of attitude towards elective single embryo transfer in addition to any legal restrictions imposed. For clinical studies, the outcome measure will depend on the hypothesis tested, and investigators should remain free to choose the appropriate primary outcome measure.