METABOLIC IMAGING OF PATIENTS WITH INTRACRANIAL TUMORS - H-1 MR SPECTROSCOPIC IMAGING AND PET
METABOLIC IMAGING OF PATIENTS WITH INTRACRANIAL TUMORS - H-1 MR SPECTROSCOPIC IMAGING AND PET
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DOI：
10.1148/radiology.176.3.2389038
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发表时间：
1990-09-01
期刊：
影响因子：
19.7
通讯作者：
HEISS, WD
中科院分区：
文献类型：
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作者：
LUYTEN, PR;MARIEN, AJH;HEISS, WD
获得了颅内肿瘤患者的氢-1磁共振（MR）光谱图像。以7 mm的名义空间分辨率和25 mm的切片厚度重建了N-乙酰天门冬氨酸、胆碱、乳酸和肌酸浓度的代谢物图。代谢物图显示了整个肿瘤中代谢物浓度的变化。在一名患者中，观察到胆碱浓度在肿瘤的一部分中增加，但在另一部分中减少。在另一名患者中，N-乙酰天冬氨酸的浓度在肿瘤的一部分中极低，但在肿瘤的另一部分中仅略有增加。在所有患者中观察到乳酸盐。在一名患者中，进行了正电子发射断层扫描（PET）和MR光谱成像的联合测量。这表明，用H-1 MR光谱成像测量的乳酸盐浓度增加与用氟-18氟-2-脱氧葡萄糖PET测量的葡萄糖摄取增加在地形上相对应。结合磁共振波谱和PET测量提供了一个机会，调查，比以前更详细，葡萄糖摄取和catalysts颅内肿瘤。
Hydrogen-1 magnetic resonance (MR) spectroscopic images of patients with intracranial tumors were obtained. Metabolite maps of N-acetyl aspartate, choline, lactate, and creatine concentrations were reconstructed with a nominal spatial resolution of 7 mm and a sectuon thickness of 25 mm. The metabolite maps showed variations in metabolite concentrations across the tumor. In one patient, it was observed that choline concentration was increased in one part of the tumor but decreased in another part. In another patient, the concentration of N-acetyl aspartate was extremely low in one part of the tumor but only slightly increased in another part of the tumor. Lactate was observed in all patients. In one patient, a combined measurement made with positron emission tomography (PET) and MR spectroscopic imaging was performed. This demonstrated that increased lactate concentration measured with H-1 MR spectroscopic imaging corresponded topographically with increased glucose uptake measured with fluorine-18 fluoro-2-deoxyglucose PET. Combined MR spectroscopic and PET measurements provide an opportunity to investigate, in greater detail than before, glucose uptake and catabolism by intracranial tumors.