CAMPYLOBACTER-PYLORI ANTIBODIES IN HUMANS
CAMPYLOBACTER-PYLORI ANTIBODIES IN HUMANS
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DOI：
10.7326/0003-4819-109-1-11
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发表时间：
1988-07-01
影响因子：
39.2
通讯作者：
BLASER, MJ
中科院分区：
文献类型：
--
作者：
PEREZPEREZ, GI;DWORKIN, BM;BLASER, MJ
研究目的：确定血清抗幽门弯曲菌抗体检测的诊断价值，并利用这些检测方法确定幽门弯曲菌的患病率。健康人群中的幽门螺杆菌感染。设计图：对因上消化道症状接受内镜检查的患者、其他胃肠道疾病患者和健康对照者的调查。设置”门诊病人参加内窥镜套房在两个大学附属医疗中心。患者：120例胃镜检查患者，61例下肠道疾病患者和166例健康对照。干预措施：检测血清中C.特异性IgA、IgG和IgM抗体。幽门。测量和主要结果：与其他革兰氏阴性病原体的吸收表明，IgG和伊加检测，但不是IgM检测，是特异性的C。幽门。C. pylori感染者和经组织学诊断为胃炎的患者，其伊加和IgG水平显著高于未检出C.幽门或胃炎。伊加和IgG检测阳性的敏感性和特异性均大于93%。在健康人群中，20岁以下的患者很少见到IgG和伊加抗体，但抗体患病率随着年龄的增长而增加，60岁以上的患者达到50%。高伊加和IgG水平至C。接受测试的五名受试者的幽门螺杆菌保持稳定超过1年，这表明该生物体至少持续了这段时间。在61例急性细菌性肠炎、急性胰腺炎、克罗恩病或溃疡性结肠炎患者中，pylori与年龄一致，与当前疾病无关。结论：C.幽门螺杆菌感染与活动性胃炎密切相关，可通过血清学检测进行诊断。成年后开始感染，患病率随年龄增长而增加。
Study Objective: To determine the diagnostic value of assays to measure serum antibodies to Campylobacter pylori, and to use these assays to determine the prevalence of C. pylori infection in a healthy population. Design: A survey of patients having endoscopies for upper gastrointestinal symptoms, patients with other gastrointestinal illnesses, and healthy controls. Setting" Outpatients attending endoscopy suites in two university-affiliated medical centers. Patients: One hundred and twenty patients who had gastroduodenscopies, 61 patients with lower intestinal illnesses, and 166 healthy controls. Intervention: Assay to detect serum IgA, IgG, and IgM antibodies specific for C. pylori. Measurements and Main Results: Absorption with other gram-negative pathogens showed that IgG and IgA assays, but not IgM assays, were specific for C. pylori. In patients in whom C. pylori had been isolated and who had gastritis diagnosed by histologic methods, significantly higher mean IgA and IgG levels were seen compared with patients without demonstrable C. pylori or gastritis. The sensitivity and specificity of a positive value in both IgA and IgG assays were more than 93%. Among healthy persons, IgG and IgA antibodies were rarely seen in patients less than 20 years old, but antibody prevalence progressed with age, reaching 50% in patients more than 60 years old. High IgA and IgG levels to C. pylori in five persons tested remained stable for more than 1 year, suggesting the organism persists for at least that period. In 61 patients with acute bacterial enteritis, acute pancreatitis, Crohn disease, or ulcerative colitis, prevalence of antibodies to C. pylori was consistent with age and unrelated to current disease. Conclusions: C. pylori infection, which is highly associated with active gastritis, may be diagnosed by serologic assay. Acquisition of infection begins in adult life, and prevalence increases with age.