The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors.
The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors.
复制标题
调节氧化应激诱导的铁死亡的分子机制及肿瘤治疗策略
DOI：
10.1155/2020/8810785
复制
发表时间：
2020
影响因子：
--
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Zhu J;Xiong Y;Zhang Y;Wen J;Cai N;Cheng K;Liang H;Zhang W
铁下垂是一种非典型的调节性细胞死亡，不同于细胞凋亡、坏死、下垂和自噬。铁下垂的特征是在抗氧化剂系统失效后，铁离子对细胞膜的氧化破坏。铁下垂的敏感性受到一系列生物过程的严格调控，包括铁、氨基酸和多不饱和脂肪酸的代谢，以及谷胱甘肽(GSH)、NADPH、辅酶Q10(CoQ10)和磷脂的相互作用。氧化应激(ROS)水平升高是癌症的标志，而铁下垂是营养代谢和氧化还原生物学之间的纽带。靶向下垂治疗可能是一种有效的、选择性的肿瘤治疗方法。铁性下垂发生的潜在分子机制仍不够深入。这篇综述将简要总结铁下垂的过程，并介绍铁下垂级联中的关键分子。此外，我们还对肿瘤代谢中铁下垂的氧化还原作用的发生和调控进行了综述。肿瘤抑制因子和表观遗传调节因子在肿瘤细胞铁性下垂中的作用也将被描述。最后，将对可用于诱发铁性下垂的旧药物进行表征，以期更有效、更经济地实现药物再利用和癌症治疗的新药物组合。
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system's failure. The sensitivity of ferroptosis is tightly regulated by a series of biological processes, the metabolism of iron, amino acids, and polyunsaturated fatty acids, and the interaction of glutathione (GSH), NADPH, coenzyme Q10 (CoQ10), and phospholipids. Elevated oxidative stress (ROS) level is a hallmark of cancer, and ferroptosis serves as a link between nutrition metabolism and redox biology. Targeting ferroptosis may be an effective and selective way for cancer therapy. The underlying molecular mechanism of ferroptosis occurrence is still not enough. This review will briefly summarize the process of ferroptosis and introduce critical molecules in the ferroptotic cascade. Furthermore, we reviewed the occurrence and regulation of reduction-oxidation (redox) for ferroptosis in cancer metabolism. The role of the tumor suppressor and the epigenetic regulator in tumor cell ferroptosis will also be described. Finally, old drugs that can be repurposed to induce ferroptosis will be characterized, aiming for drug repurposing and novel drug combinations for cancer therapy more efficiently and economically.
登录
查看更多内容
ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
9
作者：
Bi, Jianling;Yang, Shujie;Meng, Xiangbing
通讯作者：
Meng, Xiangbing
影响因子：
4.8
作者：
Alam, J;Stewart, D;Cook, JL
通讯作者：
Cook, JL