TTF1 Expression in Pulmonary Metastatic Rectal Adenocarcinoma
TTF1 Expression in Pulmonary Metastatic Rectal Adenocarcinoma
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DOI：
10.1155/2018/6405125
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发表时间：
2018-01-01
影响因子：
0.7
通讯作者：
Bellan, Cristiana
中科院分区：
文献类型：
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作者：
Aversa, Sara;Bellan, Cristiana
甲状腺转录因子 (TTF-1) 是一种组织特异性核转录因子，在发育中的甲状腺、呼吸道上皮和间脑中表达。 TTF-1被认为在大多数甲状腺肿瘤和肺肿瘤的重要亚类中特异性表达。然而，最近对其在肺外癌中表达的研究表明，TTF-1 对于肺癌和甲状腺癌的特异性并不像以前认为的那样：在其他器官（如卵巢、子宫内膜、结肠和乳腺癌）以及一些中枢神经系统肿瘤中，可以观察到该标记物的阳性，尽管频率要低得多。医学文献中已有TTF-1阳性结肠腺癌患者的病例报告，但TTF-1阳性直肠腺癌病例仅有少数。我们介绍了一名患有肺转移的直肠腺癌患者的病例，经免疫组织化学检查发现 TTF-1 呈阳性。还包括对现有文献的回顾。
Thyroid transcription factor (TTF-1) is a tissue-specific nuclear transcription factor expressed developing thyroid, respiratory epithelium, and diencephalon. TTF-1 is thought to be expressed specifically in most thyroid tumors and in a significant subset of pulmonary neoplasms. However, recent studies on its expression in extrapulmonary carcinomas have demonstrated that TTF-1 is not as specific for lung and thyroid carcinomas as was previously thought: positivity of this marker can be observed, although much less frequently, in some carcinomas arising in other organs, such as the ovaries, endometrium, colon, and breast, as well as in some tumors of the central nervous system. Case reports of patients with TTF-1-positive colon adenocarcinoma are present in medical literature, but there are only a few cases of TTF-1-positive rectal adenocarcinoma. We present the case of a patient with rectal adenocarcinoma with lung metastasis found to be TTF-1-positive on immunohistochemistry. A review of the available literature is also included.