Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases.

Bacterial Infections Associated with Immunosuppressive Agents Commonly Used in Patients with Interstitial Lung Diseases.
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DOI:
10.3390/pathogens12030464
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发表时间:
2023-03-15
期刊:
Pathogens (Basel, Switzerland)
影响因子:
--
通讯作者:
Sadikot RT
Sadikot RT
中科院分区:
其他
文献类型:
--
作者:
Chaaban S;Sadikot RT

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大约有200种不同类型的间质性肺病(ILD),评估疑似ILD患者的关键初始步骤是获得适当的诊断。一些ILD对免疫抑制剂有反应,而免疫抑制在其他ILD中可能是有害的,因此治疗是基于考虑患者风险因素的最有把握的诊断。免疫抑制药物有可能导致大量的,也许危及生命的,细菌感染的病人。然而,缺乏间质性肺病患者免疫抑制治疗引起细菌感染风险的数据。我们在此回顾了ILD患者(不包括结节病)中使用的免疫抑制治疗,强调了其细菌感染的风险,并讨论了导致感染风险增加的潜在机制。
There are about 200 different types of interstitial lung disease (ILD), and a crucial initial step in the assessment of a patient with suspected ILD is achieving an appropriate diagnosis. Some ILDs respond to immunosuppressive agents, while immunosuppression can be detrimental in others, hence treatment is based on the most confident diagnosis with consideration of a patient’s risk factors. Immunosuppressive medications have the potential to result in substantial, and perhaps life-threatening, bacterial infections to a patient. However, data on the risk of bacterial infections from immunosuppressive treatment specifically in patients with interstitial lung disease is lacking. We hereby review the immunosuppressive treatments used in ILD patients excluding sarcoidosis, highlight their risk of bacterial infections, and discuss the potential mechanisms that contribute to the increased risk of infections.
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