Gonadectomy unmasks an inhibitory effect of progesterone on amygdala kindling in male rats
Gonadectomy unmasks an inhibitory effect of progesterone on amygdala kindling in male rats
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DOI：
10.1016/s0006-8993(00)03147-4
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发表时间：
2001-01-19
期刊：
影响因子：
2.9
通讯作者：
MacLusky, NJ
中科院分区：
文献类型：
--
作者：
Edwards, HE;Mo, V;MacLusky, NJ
Previous studies have suggested that the effects of progesterone on kindling in rats may be sexually differentiated, significant effects of physiological levels of progesterone being observed only in females. The present study demonstrates that this difference results from the hormones secreted by the testes. Thus, in orchidectomized males, progesterone induces a delay in the onset of amygdala-kindled seizures similar to that observed in females. (C) 2001 Elsevier Science B.V. All rights reserved.
