Long-term exposure to high temperature associated with the incidence of major depressive disorder
Long-term exposure to high temperature associated with the incidence of major depressive disorder
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DOI：
10.1016/j.scitotenv.2018.12.434
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发表时间：
2019-04-01
影响因子：
9.8
通讯作者：
Guo, Yue-Liang Leon
中科院分区：
文献类型：
--
作者：
Chen, Nai-Tzu;Lin, Po-Hsiu;Guo, Yue-Liang Leon
据报道，温度对精神障碍有急性影响。然而，长期暴露在温度下的影响尚不清楚，特别是在较温暖的地区。这项研究旨在评估长期接触温度与严重抑郁障碍(MDD)发生率之间的关系。本研究利用2005年台湾全国纵向健康保险资料库，进行一项以人口为基础的回溯性研究。2003年至2013年，对未诊断为MDD的受试者进行了MDD发生情况的跟踪调查。气温(摄氏度)、日照时数(小时/天)和降水量(毫米/天)等天气因素是台湾中央气象局气象监测站收集的11年日均数据。使用COX比例风险模型检验MDD发病率与天气因素之间的关系。调整了包括年龄、性别和保险金额在内的协变量。总共跟踪了9,539,752人年。居住在长期气温20-23摄氏度地区的人患MDD的风险最低。平均气温在23摄氏度的地区的居民患MDD的风险更高，每增加1摄氏度就会增加7%(95%CI=2-12%)。老年人更容易受到这种高温暴露的影响。在老年人中，男性比女性更容易患上与高温相关的MDD(HR=1.18比1.14)。然而，年轻的一组显示出相反的发现(即女性1.07；男性1.04)。长期居住在极端寒冷或炎热的地区可能会增加MDD发病的风险，特别是较高的温度。在全球变暖的情况下，这些发现具有重大的健康影响，值得进一步证实。(C)2019爱思唯尔B.V.保留所有权利。
Temperature was reported to have acute effects on mental disorders. However, the effect of long-term temperature exposure is unclear, especially in warmer regions. This research aimed to evaluate the association between long-term exposure to temperature and the incidence of major depressive disorder (MDD). A retrospective population-based study was conducted using Taiwan nationwide Longitudinal Health Insurance Database 2005. Subjects without MDD diagnosis were followed from 2003 to 2013 for MDD occurrence. Weather factors including temperature (degrees C), sunshine duration (hrs/day), and precipitation (mm/day) were 11-year average of daily data collected from weather monitoring stations of Taiwan Central Weather Bureau. Cox proportional hazard model was performed to examine the association between MDD incidence and weather factors. Covariates including age, gender, and insurance amount were adjusted. A total of 9,539,752 person-years were followed. People residing in regions with long-term temperature of 20-23 degrees C had the lowest risk of developing MDD. Risk for MDD incidence was higher among residents in regions with average temperature >23 degrees C, at 7% increase per 1 degrees C increment (95% CI=2-12%). The elderly was more vulnerable to such impact of heat exposure. For the elderly, males were more susceptible to heat-related MDD than females (HR = 1.18 vs. 1.14). However, the younger group showed a reverse finding (i.e. females 1.07 > males 1.04). Long-term residence in regions with extreme cold or heat may increase the risk of MDD incidence, especially higher temperature. Under global warming, these findings have great health implications and warrant further confirmation. (c) 2019 Elsevier B.V. All rights reserved.