PREFRONTAL CORTEX OF THE MOUSE DEFINED AS CORTICAL PROJECTION AREA OF THE THALAMIC MEDIODORSAL NUCLEUS
PREFRONTAL CORTEX OF THE MOUSE DEFINED AS CORTICAL PROJECTION AREA OF THE THALAMIC MEDIODORSAL NUCLEUS
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DOI：
10.1159/000121636
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发表时间：
1981-01-01
影响因子：
1.7
通讯作者：
MARKOWITSCH, HJ
中科院分区：
文献类型：
--
作者：
GULDIN, WO;PRITZEL, M;MARKOWITSCH, HJ
在小鼠中，少量的辣根过氧化物酶被注入额叶的不同部位。在大量的小鼠中，选择了18只具有典型注射的小鼠，这些注射一起覆盖了大脑前半部分的大部分皮质，并对它们的逆行标记的丘脑细胞进行了详细的描述和说明。特别强调内侧背侧核的皮质投射，它被认为是确定前额叶皮质的位置和范围。结果表明，小鼠S前额叶皮质的形态结构与大鼠十分相似。它包括鼻沟内和鼻沟背侧的一小块区域，以及前皮质内侧半部分的相对较大的区域。额极的背端由相当数量的来自背内侧核的传入神经到达。这最后一种投射是否也存在于老鼠身上，目前仍存在争议。与大鼠一样，只有沟前额叶皮质似乎只有背内侧细胞才能到达，而其余的前额叶皮质区域有来自前内侧核的重叠投射。尽管小鼠额叶内相当大的区域由内侧背向传入神经到达，但前额叶皮质这一定义的重要性和有用性仍受到质疑。
In the mouse small amounts of horseradish peroxidase were injected iontophoretically into different portions of the frontal lobe. Of a large number of mice, 18 with typical injections which together covered most of the anterior half of the cortex were selected, and their retrogradely labeled thalamic cells were described and illustrated in detail. Special emphasis was laid on the cortical projections of the mediodorsal nucleus which were considered to define locus and extent of the prefrontal cortex. The results reveal that topographically the extent of the mouse''s prefrontal cortex closely resembles that of the rat. It includes a small area within and dorsal to the rhinal sulcus and a comparatively larger region within the medial half of the anterior cortex. The dorsal tip of the frontal pole is reached by a considerable number of afferents from the mediodorsal nucleus. Whether this last projection also exists in the rat is still disputed. As in the rat, only the sulcal prefrontal cortex seems to be reached by mediodorsal cells alone, whereas the rest of the prefrontal cortical fields have overlapping projections from the anteromedial nucleus. Although a considerable area within the frontal lobe of the mouse is reached by mediodorsal afferents, the significance and usefulness of this definition of the prefrontal cortex is questioned.