Survival and cause-specific mortality in inflammatory bowel disease: a population-based cohort study.
Survival and cause-specific mortality in inflammatory bowel disease: a population-based cohort study.
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炎症性肠病的生存率和特定原因死亡率：一项基于人群的队列研究。
DOI：
10.1053/gast.1996.v110.pm8613037
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发表时间：
1996
期刊：
影响因子：
29.4
通讯作者：
A. Ahlbom
中科院分区：
文献类型：
--
作者：
P. Persson;O. Bernell;C. Leijonmarck;B. Farahmand;G. Hellers;A. Ahlbom
背景和目标
一项基于人群的队列研究对1955至1984年间在斯德哥尔摩确诊的1251名克罗恩病患者和1547名溃疡性结肠炎患者进行了研究，以检查患者的存活率、存活率随时间的变化以及特定原因的死亡率。
方法
这组患者在国家死因登记中进行了跟踪调查，直到1990年。国家死亡率被用来进行比较。
结果
15年后，克罗恩病的观察生存率为93.7%(95%可信区间，91.8%-95.7%)，溃疡性结肠炎为94.2%(95%可信区间，92.4%-96.1%)。总体而言，在克罗恩病中发生了174例死亡，而预期为115.42例(标准化死亡率比为1.5；95%可信区间为1.29-1.75)。在溃疡性结肠炎中，发生了255例死亡，而预期为186.78例(标准化死亡率比为1.37%，95%可信区间为1.201.54)。炎症性肠病是死亡率升高的主要原因，但溃疡性结肠炎中结直肠癌、哮喘和非酒精相关肝病的死亡率增加；溃疡性结肠炎和克罗恩病中其他胃肠道疾病的死亡率增加。
结论
目前研究中的数据与炎症性肠病患者与普通人群相比死亡率增加的假设是一致的。
BACKGROUND & AIMS
A population-based cohort study of 1251 subjects with Crohn's disease and 1547 subjects with ulcerative colitis, diagnosed in Stockholm between 1955 and 1984, was performed to examine the survival, changes in survival over time, and cause-specific mortality.
METHODS
The cohort of patients was followed up in the National Cause-of-Death register until 1990. National mortality rates were used for comparisons.
RESULTS
The observed vs. expected survival rate after 15 years was 93.7% (95% confidence interval [CI], 91.8%-95.7%) for Crohn's disease and 94.2% (95% CI, 92.4%-96.1%) for ulcerative colitis. Overall, 174 deaths occurred vs 115.42 expected (standardized mortality ratio, 1.51; 95% CI, 1.29-1.75) in Crohn's disease. In ulcerative colitis, 255 deaths occurred compared with 186.78 expected (standardized mortality ration, 1.37; 95% CI, 1.20-1.54). Inflammatory bowel disease was the major contributor to the elevated mortality rate, but mortality from colorectal cancer, asthma, and non-alcohol-related liver diseases was increased in ulcerative colitis; mortality from other gastrointestinal diseases was increased in ulcerative colitis as well as in Crohn's disease.
CONCLUSIONS
Data in the present study are compatible with the hypothesis that subjects with inflammatory bowel disease have an increased mortality compared with the general population.