Telomeric sequences localization and G-banding patterns in the identification of a polymorphic chromosomal rearrangement in the rodent Akodon cursor (2n=14, 15 and 16)
Telomeric sequences localization and G-banding patterns in the identification of a polymorphic chromosomal rearrangement in the rodent Akodon cursor (2n=14, 15 and 16)
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DOI：
10.1023/a:1018463401887
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发表时间：
1997-06-01
影响因子：
2.6
通讯作者：
YonenagaYassuda, Y
中科院分区：
文献类型：
--
作者：
Fagundes, V;ViannaMorgante, AM;YonenagaYassuda, Y
Akodon光标是一个特殊的例子，高染色体变异性，显示二倍体数从14至16和基本数（FN）从18至26作为一个复杂的重排在第1杆和臂间倒位在三个常染色体对的结果。二倍体数目的差异是由于在2n=14核型中存在一个大的中部着丝粒对1，在2n=15核型中存在一个大的中部着丝粒对1和两个不同的亚中部着丝粒（la和Ib），在2n=16核型中纯合的la和Ib亚中部着丝粒对。染色体Ia和Ib分别与大中部着丝粒1的短臂和长臂具有同源性。在本文中，荧光原位杂交（FISH）与端粒序列和G-显带的基础上的证据表明，臂间倒位和融合的染色体la和Ib是可能的重排引起的大中部着丝粒1。
Akodon cursor is an exceptional example of high chromosomal variability, displaying diploid numbers from 14 to 16 and fundamental numbers (FN) from 18 to 26 as the result of a complex rearrangement in par 1 and pericentric inversions in three autosomal pairs. The difference in the diploid number is due to the presence of a large metacentric pair 1 in the 2n=14 karyotype, a large metacentric 1 and two different submetacentrics (la and Ib) in 2n=15 and la and Ib submetacentric pairs in homozygosis in the 2n=16 karyotype. Chromosomes la and Ib share homology with the short and long arms of the large metacentric 1 respectively. In this paper, evidence based on fluorescence in situ hybridization (FISH) with telomeric sequences and G-banding indicates that pericentric inversions and fusion of chromosomes la and Ib are the probable rearrangements giving rise to the large metacentric 1.