Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging
Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging
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DOI：
10.1118/1.1534109
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发表时间：
2003-02-01
期刊：
影响因子：
3.8
通讯作者：
Yodh, AG
中科院分区：
文献类型：
--
作者：
Culver, JP;Choe, R;Yodh, AG
乳腺三维扩散光学断层扫描（DOT）需要大的数据集，即使是中等分辨率（1厘米）。我们提出了一种混合DOT系统，它结合了有限数量的频域（FD）测量与一个大的连续波（CW）测量。FD测量用于定量确定组织平均吸收和散射系数。用透镜耦合CCD收集的较大cw数据集（105个测量）允许1升组织体积的3D DOT重建。为了解决大型数据集和3D体积的计算复杂性，我们采用并行计算的基于有限差分的重建。组织体模测量评价成像性能。这些测试包括：点扩散函数分辨率测量、单个物体的大小和对比度表征、视场测量和成分浓度的光谱表征。我们还报告在体内测量。健康乳房的平均组织光学特性用于推断氧合血红蛋白和脱氧血红蛋白浓度。利用粘附在健康乳房表面的肿瘤模拟目标的差分成像评估生理波动对图像噪声的影响。该断层扫描系统提供了强大的，定量的，完整的3D图像重建与高数据吞吐量，单探测器组织耦合路径，大（1L）成像域的优点。此外，我们发现，点扩散函数测量提供了一个有用的和全面的系统性能的表示。(C)2003年美国医学物理学家协会。
Three-dimensional diffuse optical tomography (DOT) of breast requires large data sets for even modest resolution (1 cm). We present a hybrid DOT system that combines a limited number of frequency domain (FD) measurements with a large set of continuous wave (cw) measurements. The FD measurements are used to quantitatively determine tissue averaged absorption and scattering coefficients. The larger cw data sets (105 measurements) collected with a lens coupled CCD, permit 3D DOT reconstructions of a 1-liter tissue volume. To address the computational complexity of large data sets and 3D volumes we employ finite difference based reconstructions computed in parallel. Tissue phantom measurements evaluate imaging performance. The tests include the following: point spread function measures of resolution, characterization of the size and contrast of single objects, field of view measurements and spectral characterization of constituent concentrations. We also report in vivo measurements. Average tissue optical properties of a healthy breast are used to deduce oxy- and deoxy-hemoglobin concentrations. Differential imaging with a tumor simulating target adhered to the surface of a healthy breast evaluates the influence of physiologic fluctuations on image noise. This tomography system provides robust, quantitative, full 3D image reconstructions with the advantages of high data throughput, single detector-tissue coupling path, and large (1L) imaging domains. In addition, we find that point spread function measurements provide a useful and comprehensive representation of system performance. (C) 2003 American Association of Physicists in Medicine.