Immunoregulation and natural killer cells.
Immunoregulation and natural killer cells.
复制标题
免疫调节和自然杀伤细胞。
DOI：
10.1016/0161-5890(82)90299-1
复制
发表时间：
1982
影响因子：
3.6
通讯作者：
R. Herberman
中科院分区：
文献类型：
--
作者：
R. Herberman
Natural killer (NK) cells have a cytotoxic activity against a variety of tumor cells and also against some microorganisms or cells infected by microbial agents. They may thereby serve as important effector cells in host resistance against disease. NK cells are present in virtually all individuals, can be activated rapidly by a wide range of stimuli, and their activities do not depend on sensitization by antigens and the development of specific immune responses. Thus, these cells may function as a first line of defense against attack by neoplastic cells or infectious agents.The issue of immunoregulation and NK cells is pertinent in two major ways:(a) a variety of positive and negative signals have been found which regulate the expression of the activity of NK cells, and (b) NK cells themselves have the ability to function as immunoregulatory cells. This brief review will illustrate these points primarily by examples from our own laboratory and by other selected, recent references. It should be noted that it has not been our intention to provide an authoritative review of the very extensive literature in this complex area. For more extensive and general reviews on NK cells, see Herberman & Holden (1978) and Herberman (1980).
前列腺素 (PGE2) 和乙醇对自然杀伤细胞溶解过程的双重作用：效应器激活和 NK 细胞-靶细胞缀合物溶解抑制。
DOI：
--
发表时间：
1980
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kendall,RA;Targan,S
通讯作者：
Targan,S