Fibrinogen/Fibrin Degradation Products in Acute Aortic Dissection
Fibrinogen/Fibrin Degradation Products in Acute Aortic Dissection
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DOI：
10.2169/internalmedicine.49.3770
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发表时间：
2010-01-01
影响因子：
1.2
通讯作者：
Tashiro, Hideki
中科院分区：
文献类型：
--
作者：
Nagaoka, Kazuhiro;Sadamatsu, Kenji;Tashiro, Hideki
背景D-二聚体升高是诊断急性主动脉夹层（AAD）的线索之一，但D-二聚体快速检测尚未在所有急诊医院得到应用。纤维蛋白原/纤维蛋白降解产物（FDP）值也是纤维蛋白溶解增强的指标，因此可能是AAD患者的有用标志物。此外，FDP值与假腔部分血栓形成之间的关系尚未阐明。患者本研究纳入了50例患者（66.5 +/- 11.2岁;中位数，66.5岁，男性受试者占系列的60.0%）2005年7月至2007年12月期间入院的AAD患者和57例急性心肌梗死患者结果AAD患者的FDP值（μ g/mL）显著高于AMI患者（40.2 ± 78.6;中位数，14.7 vs. 5.2 +/- 9.8;中位数，1.7，p
Background The elevated D-dimer value is one of the clues used to diagnose acute aortic dissection (AAD), but the rapid D-dimer assay is not used at all emergency hospitals. The fibrinogen/fibrin degradation products (FDP) value is also an indicator of enhanced fibrinolysis and may therefore be a useful marker in patients with AAD. In addition, the association between FDP values and partial thrombosis of the false lumen is not elucidated.Patients The present study enrolled 50 patients (66.5 +/- 11.2 years of age; median, 66.5 years of age, male subjects comprised 60.0% of the series) with AAD who were admitted to the hospital between July 2005 and December 2007 and 57 patients with acute myocardial infarction (AMI; 70.8 +/- 10.4 years of age; median, 71.0 years of age, male subjects comprised 71.9% of the current series) served as a control group.Results The FDP values (mu g/mL) in patients with AAD were significantly higher than those of AMI patients (40.2 +/- 78.6; median, 14.7 vs. 5.2 +/- 9.8; median, 1.7, p