Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps
Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps
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DOI：
10.1038/75776
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发表时间：
2000-06-01
影响因子：
25
通讯作者：
Ramirez, JM
中科院分区：
文献类型：
--
作者：
Lieske, SP;Thoby-Brisson, M;Ramirez, JM
不同形式的呼吸是否源自一个或多个神经网络？我们证明，脑干切片含有前Botzinger复杂的正常充氧时产生两种节奏，具有惊人的相似性，正常（“正常”）呼吸和叹息。在控制条件下，但不是在士的宁（1 μ M）的存在下，由eupneic爆发触发的severity。虽然所有的神经元在这两个活动中接受突触输入，钙通道阻滞剂镉（4 μ M）选择性地取消叹息。在缺氧，叹息停止，和eupneic活动重新配置成喘息，这就像eupnea是不敏感的4 μ M镉。这种重构伴随着突触抑制的抑制。我们的结论是，一个单一的延髓网络的基础上多种呼吸模式。
Are different forms of breathing derived from one or multiple neural networks? We demonstrate that brainstem slices containing the pre-Botzinger complex generated two rhythms when normally oxygenated, with striking similarities to eupneic ('normal') respiration and sighs. Sighs were triggered by eupneic bursts under control conditions, but not in the presence of strychnine (1 mu M). Although all neurons received synaptic inputs during both activities, the calcium channel blocker cadmium (4 mu M) selectively abolished sighs. In anoxia, sighs ceased, and eupneic activity was reconfigured into gasping, which like eupnea was insensitive to 4 mu M cadmium. This reconfiguration was accompanied by suppression of synaptic inhibition. We conclude that a single medullary network underlies multiple breathing patterns.