Predictive Effect of Mean Platelet Volume in Patients with Portal Vein Thrombosis: A Meta-analysis of Case-control Studies
Predictive Effect of Mean Platelet Volume in Patients with Portal Vein Thrombosis: A Meta-analysis of Case-control Studies
复制标题
平均血小板体积对门静脉血栓形成患者的预测作用：病例对照研究的荟萃分析
DOI：
10.1007/s11596-018-1916-z
复制
发表时间：
2018-08-01
影响因子：
2.4
通讯作者：
Hu, Yu
中科院分区：
文献类型：
--
作者：
Lin, Wen-yi;Lu, Xuan;Hu, Yu
平均血小板体积（MPV）是血小板活化的早期标志。与小血小板相比，较大的血小板会增加血小板粘附和聚集，并呈现出更高的血栓形成活性。一些研究探讨了 MPV 与门静脉血栓 (PVT) 发病率之间的关联。本研究的目的是通过荟萃分析评估 MPV 对 PVT 患者的预测效果。我们检索了Pubmed、Web of Science、SCOPUS、OVID、CNKI和CBMD，从数据库建库到2017年9月13日。纳入了符合选择标准的七项研究。基础数据的提取由两名评审员独立进行。 PVT 患者和对照之间 MPV 的平均差异采用加权平均差异 (WMD) 和 0.88 fl 的 95% 置信区间 (95% CI: 0.61-1.15) 进行汇总。由于合并中存在明显的异质性，因此选择了随机效应模型（卡方=27.12，df=6，P<000l，I（2）=77.9%）。异质性的来源是参与者原发病的差异和门静脉直径的差异。综上所述，我们的结果表明 MPV 是 PVT 患者的预测指标。
Mean platelet volume (MPV) is an early marker of platelet activation. Larger platelets, compared to small ones, increase platelet adhesion and aggregation, and present a higher thrombotic activity. Some studies have explored the association between MPV and the morbidity of portal vein thrombosis (PVT). The aim of this study was to evaluate the predictive effect of MPV in patients with PVT by a meta-analysis. We searched Pubmed, Web of Science, SCOPUS, OVID, CNKI and CBMD from database inception to September 13,2017. Seven studies in accordance with selection criteria were included. The extraction of basic data was independently conducted by two reviewers. The mean difference in MPV between PVT patients and controls were pooled with weighted mean difference (WMD) and 95% confidence interval of 0.88 fl (95% CI: 0.61-1.15). A random-effect model was chosen for an obvious heterogeneity in the pooling (Chi-square=27.12, df=6, P < 000l, I (2)=77.9%). The sources of heterogeneity were from the difference of primary disease of participants and portal vein diameter. Taken together, our results reveal that MPV is a predictive indicator in patients with PVT.