Patent Ductus Venosus and Congenital Heart Disease: A Case Report and Review.
Patent Ductus Venosus and Congenital Heart Disease: A Case Report and Review.
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DOI：
10.14740/cr777w
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发表时间：
2018-10
影响因子：
1.9
通讯作者：
Tobias JD
中科院分区：
文献类型：
--
作者：
Poeppelman RS;Tobias JD
在子宫内，静脉导管连接左门静脉和下腔静脉，允许一部分静脉血绕过肝脏返回心脏。出生后，由于心内压力的变化和内源性肾上腺素的减少，静脉导管关闭。静脉导管闭合失败可能导致半乳糖血症、低氧血症、脑病伴高氨血症和肝功能障碍。我们报告一位复杂先天性心脏病的婴儿，在手术前因静脉导管未闭而出现凝血障碍及高氨血症。先前的报告PDV在冠心病，其病因和临床后果审查，并讨论治疗方案。
In utero, the ductus venosus connects the left portal vein to the inferior vena cava, allowing a portion of the venous blood to bypass the liver and return to the heart. After birth, the ductus venosus closes due to changes in intracardiac pressures and a decrease in endogenous prostaglandins. Failure of the ductus venosus to close may result in galactosemia, hypoxemia, encephalopathy with hyperammonia, and hepatic dysfunction. We report an infant with complex congenital heart disease (CHD) who developed coagulopathy and hyperammonia during the preoperative period secondary to patent ductus venosus (PDV). Previous reports of PDV in CHD are presented, its etiology and clinical consequences reviewed, and options for therapeutic treatment discussed.