Abnormalities of magnetic resonance spectroscopy and diffusion tensor imaging are correlated with executive dysfunction in patients with ischemic leukoaraiosis
Abnormalities of magnetic resonance spectroscopy and diffusion tensor imaging are correlated with executive dysfunction in patients with ischemic leukoaraiosis
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磁共振波谱和弥散张量成像异常与缺血性脑白质疏松症患者执行功能障碍相关
DOI：
10.1016/j.jocn.2011.07.052
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发表时间：
2012-05-01
影响因子：
2
通讯作者：
Zeng, Jinsheng
中科院分区：
文献类型：
--
作者：
Li, Chuo;Ling, Xueying;Zeng, Jinsheng
缺血性白质病（ILA）患者心室周围白质弥散张量成像（DTI）结果异常。然而，潜在的病理改变及其与认知障碍的关系尚不清楚。此外，丘脑（执行功能网络中的一个重要结构）的损伤也被认为与ILA有关，但对其了解甚少。20例ILA患者和20名年龄和教育背景相似的健康志愿者接受了DTI、磁共振波谱（MRS）和神经心理学评估。在ILA患者中，我们观察到脑室前后区和丘脑的平均扩散率（MD）增加，n -乙酰天冬氨酸(NAA)/肌酸（Cr）水平降低，脑室前后区各向异性分数（FA）降低。脑室前后周白质的MD和NAA/Cr水平以及丘脑的NAA/Cr水平与执行功能相关。DTI和MRS异常与轴突和/或神经元丢失和脑室前后周围白质和丘脑功能障碍一致。本研究表明，DTI和MRS技术可用于研究脑室周围前、后白质和丘脑的病理变化；这些变化可能与ILA患者的执行功能变化有关。(C) 2011 Elsevier Ltd.版权所有。
Abnormal diffusion tensor imaging (DTI) results have been observed in the periventricular white matter in patients with ischemic leukoaraiosis (ILA). However, the underlying pathological changes and their relationship to cognitive impairments are obscure. In addition, damage in the thalamus, an important structure in the executive function network, has been suggested in ILA, but is poorly understood. Twenty patients with ILA and 20 healthy volunteers with similar ages and educational histories underwent DTI, magnetic resonance spectroscopy (MRS) and a neuropsychological assessment. In patients with ILA, we observed an increased mean diffusivity (MD) and decreased levels of N-acetylaspartate (NAA)/creatine (Cr) in the anterior and posterior periventricular region and the thalamus, as well as decreased fractional anisotropy (FA) in the anterior and posterior periventricular regions. MD and NAA/Cr levels in the anterior and posterior periventricular white matter and NAA/Cr levels in the thalamus were correlated with executive function. DTI and MRS abnormalities were consistent with axonal and/or neuronal loss and dysfunction in the anterior and posterior periventricular white matter and the thalamus. This study demonstrates that DTI and MRS techniques can be used to investigate pathological changes in the anterior and posterior periventricular white matter and the thalamus; these changes may be correlated with executive functional changes in patients with ILA. (C) 2011 Elsevier Ltd. All rights reserved.