Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Quebec Family Study
Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Quebec Family Study
复制标题
DOI：
10.1007/bf03345301
复制
发表时间：
2004-12-01
影响因子：
5.4
通讯作者：
Pérusse, L
中科院分区：
文献类型：
--
作者：
Bouchard, L;Weisnagel, SJ;Pérusse, L
肥胖和胰岛素抵抗是 2 型糖尿病的共同特征。一种名为抵抗素的新蛋白质已被证明由小鼠脂肪细胞分泌并影响胰岛素敏感性。本研究的目的是调查人类抵抗素基因的一种多态性（g-420C>G）与肥胖和葡萄糖代谢相关表型之间的关联。我们通过小测序方法对参与魁北克家庭研究 (QFS) 的 725 名成年受试者（包括 42 名糖尿病患者）进行了基因分型。四十二人是糖尿病受试者。测量的表型包括：体重指数（BMI）和腰围（WC）、通过水下称重评估的体脂百分比（PFAT）和脂肪量（FM）、通过计算机断层扫描评估的腹部总脂肪、皮下脂肪和内脏脂肪以及空腹血糖、胰岛素和C肽及其对口服葡萄糖耐量试验（OGTT）的反应。通过协方差分析 (ANCOVA) 分别对非糖尿病男性（人数=280）和女性（人数=403）进行基因型比较。在男性中，g-420 G 纯合子的内脏脂肪较少（p
Obesity and insulin resistance are common features of Type 2 Diabetes. A new protein called resistin has been shown to be secreted by adipocytes in mice and to influence insulin sensitivity. The goal of the present study was to investigate the associations between one polymorphism (g-420C>G) of the human resistin gene and phenotypes related to adiposity and glucose metabolism. We genotyped 725 (including 42 diabetics) adult subjects participating in the Quebec Family Study (QFS) by a minisequencing method. Forty-two were diabetic subjects. Phenotypes measured were: body mass index (BMI) and waist circumference (WC), % body fat (PFAT) and fat mass (FM) assessed by under water weighing, abdominal total, subcutaneous and visceral fat assessed by computed tomography and fasting plasma glucose, insulin and C-peptide and their responses to an oral glucose tolerance test (OGTT). Comparisons between genotypes were performed in non-diabetic men (no.=280) and women (no.=403) separately by analyses of covariance (ANCOVA). Among men, g-420 G homozygotes had less visceral fat (p