Non-Canonical Functions of Myeloperoxidase in Immune Regulation, Tissue Inflammation and Cancer.
Non-Canonical Functions of Myeloperoxidase in Immune Regulation, Tissue Inflammation and Cancer.
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DOI：
10.3390/ijms232012250
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发表时间：
2022-10-14
影响因子：
5.6
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中科院分区：
文献类型：
--
作者：
髓过氧化物酶（MPO）是中性粒细胞中表达最丰富的蛋白质之一。它是抗菌防御系统的关键组成部分，通过产生活性氧（ROS）促进微生物杀灭。有趣的是，新出现的证据表明，除了MPO公认的典型抗菌功能外，它还可以直接或间接影响免疫细胞和组织在稳态和疾病状态下的反应。在这里，我们强调了MPO的新出现的非经典功能，包括其对中性粒细胞寿命的影响，炎症的激活和运输，其与其他免疫细胞的相互作用，以及这些相互作用如何塑造疾病的结果。我们进一步讨论了MPO与内皮细胞和上皮细胞、中枢神经系统（CNS）特化细胞之间的相互作用及其在癌症进展中的作用。这种多样的功能和MPO与许多炎性疾病的关联使其成为旨在解决炎症和限制炎症相关组织损伤的治疗的有吸引力的靶标。然而，尽管认为MPO抑制是一种潜在的治疗方法，但必须考虑MPO活性对健康和疾病中各种细胞区室的不同影响。
Myeloperoxidase (MPO) is one of the most abundantly expressed proteins in neutrophils. It serves as a critical component of the antimicrobial defense system, facilitating microbial killing via generation of reactive oxygen species (ROS). Interestingly, emerging evidence indicates that in addition to the well-recognized canonical antimicrobial function of MPO, it can directly or indirectly impact immune cells and tissue responses in homeostatic and disease states. Here, we highlight the emerging non-canonical functions of MPO, including its impact on neutrophil longevity, activation and trafficking in inflammation, its interactions with other immune cells, and how these interactions shape disease outcomes. We further discuss MPO interactions with barrier forming endothelial and epithelial cells, specialized cells of the central nervous system (CNS) and its involvement in cancer progression. Such diverse function and the MPO association with numerous inflammatory disorders make it an attractive target for therapies aimed at resolving inflammation and limiting inflammation-associated tissue damage. However, while considering MPO inhibition as a potential therapy, one must account for the diverse impact of MPO activity on various cellular compartments both in health and disease.
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影响因子：
8.3
作者：
Coulibaly AP;Pezuk P;Varghese P;Gartman W;Triebwasser D;Kulas JA;Liu L;Syed M;Tvrdik P;Ferris H;Provencio JJ
通讯作者：
Provencio JJ
影响因子：
37.8
作者：
Baldus, S;Heeschen, C;Hamm, CW
通讯作者：
Hamm, CW
影响因子：
29.4
作者：
Bui, Triet M.;Butin-Israeli, Veronika;Sumagin, Ronen
通讯作者：
Sumagin, Ronen
影响因子：
4.3
作者：
Andelid, Kristina;Bake, Bjorn;Ekberg-Jansson, Ann
通讯作者：
Ekberg-Jansson, Ann
影响因子：
3.6
作者：
Buss, IH;Senthilmohan, R;Winterbourn, CC
通讯作者：
Winterbourn, CC