The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair.
The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair.
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DOI：
10.1007/s12017-009-8086-x
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发表时间：
2009
影响因子：
3.5
通讯作者：
Mattson, Mark P.
中科院分区：
文献类型：
--
作者：
Hutchison, Emmette R.;Okun, Eitan;Mattson, Mark P.
关键词：
MicroRNAs(MiRNAs)被认为在中枢神经系统的发育和疾病过程中发挥重要作用。在许多神经退行性疾病、发育障碍和中风中，miRNAs似乎处于失调状态。每个miRNA都有能力调节数百个信使RNA转录本，既可以导致mRNA的降解，也可以通过抑制蛋白质翻译来实现。最近的发现表明，通过恢复或抑制由疾病病理改变的miRNAs，最终可能治疗一些神经疾病。病毒传递和注射模拟或抑制特定miRNAs的修饰寡核苷酸在模型系统中都是有效的。还产生了用于抑制特定转录本的人造miRNAs。疾病和损伤引起的miRNA表达的变化也为改进诊断工具提供了可能性。最后，miRNAs已被证明可以控制细胞的增殖和规范，这表明在培养细胞中操纵miRNAs可以更方便地产生用于移植的纯细胞群体。
MicroRNAS (miRNAs) have been suggested to play important roles in the central nervous system during development as well as disease. miRNAs appear to be dysregulated in a number of neurodegenerative diseases, developmental disorders and as a result of stroke. Each miRNA has the ability to regulate hundreds of messenger RNA transcripts, both by causing degradation of the mRNA and by inhibition of protein translation. Recent findings suggest that it may eventually be possible to treat some neurological disorders by restoring or inhibiting miRNAs altered by disease pathology. Both viral delivery and administration of modified oligonucleotides mimicking or inhibiting specific miRNAs have been effective in model systems. Artificial miRNAs have also been generated for the repression of specific transcripts. Alteration of miRNA expression by disease and insult also holds the potential for improved diagnostic tools. Lastly, miRNAs have been shown to control cellular proliferation and specification, suggesting that manipulation of miRNAs in cultured cells could result in more convenient generation of pure cell populations for transplantation.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
DOI：
10.1038/jcbfm.2008.157
发表时间：
2009-04
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
56.9
作者：
Kim, Jongpil;Inoue, Keiichi;Abeliovich, Asa
通讯作者：
Abeliovich, Asa
影响因子：
5.2
作者：
Krichevsky, Anna M.;Sonntag, Kai-C.;Kosik, Kenneth S.
通讯作者：
Kosik, Kenneth S.
DOI：
10.1073/pnas.0710263105
发表时间：
2008-04-29
影响因子：
11.1
作者：
Hebert, Sebastien S.;Horre, Katrien;De Strooper, Bart
通讯作者：
De Strooper, Bart