Advances and Challenges in Assessing 2-Hydroxyglutarate in Gliomas by Magnetic Resonance Spectroscopy: A Short Review
Advances and Challenges in Assessing 2-Hydroxyglutarate in Gliomas by Magnetic Resonance Spectroscopy: A Short Review
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DOI：
10.4172/neuropsychiatry.1000525
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
M. Natsumeda;H. Igarashi;K. Motohashi;Yuji Suzuki;M. Ohkubo;K. Okamoto;Masaki Watanabe;T. Nakada;Y. Fujii
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文献类型：
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作者：
M. Natsumeda;H. Igarashi;K. Motohashi;Yuji Suzuki;M. Ohkubo;K. Okamoto;Masaki Watanabe;T. Nakada;Y. Fujii
代谢产物2-羟基戊二酸（2 HG）在异柠檬酸脱氢酶（IDH）突变型胶质瘤中积累，并且高水平的2 HG可以通过磁共振波谱（MRS）在活体人脑中无创检测。能够检测与重要基因突变相关的代谢物的概念在神经肿瘤学和神经放射学领域产生了相当大的兴奋。然而，在我们可以将其用作做出临床决策的工具之前，可靠地检测2 HG仍然存在挑战。本文综述了MRS在2 HG评估中的进展和挑战。
The metabolite 2-hydroxyglutarate (2HG) accumulates in isocitrate dehydrogenase (IDH)- mutant gliomas and high-levels of 2HG can be non-invasively detected in living human brain by magnetic resonance spectroscopy (MRS). The concept of being able to detect a metabolite associated with an important gene mutation has generated considerable excitement in the fields of neurooncology and neuroradiology. However, challenges remain in reliably detecting 2HG before we can use it as a tool for making clinical decisions. In this review, we outline the advances and challenges in assessing 2HG by MRS.