Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration.
Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration.
复制标题
肌肉骨骼动态平衡、疾病和再生中的细胞衰老。
DOI：
10.1038/s41413-021-00164-y
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发表时间：
2021-09-10
期刊：
影响因子：
12.7
通讯作者：
Elisseeff JH
中科院分区：
文献类型：
--
作者：
Wan M;Gray-Gaillard EF;Elisseeff JH
Emerging insights into cellular senescence highlight the relevance of senescence in musculoskeletal disorders, which represent the leading global cause of disability. Cellular senescence was initially described by Hayflick et al. in 1961 as an irreversible nondividing state in in vitro cell culture studies. We now know that cellular senescence can occur in vivo in response to various stressors as a heterogeneous and tissue-specific cell state with a secretome phenotype acquired after the initial growth arrest. In the past two decades, compelling evidence from preclinical models and human data show an accumulation of senescent cells in many components of the musculoskeletal system. Cellular senescence is therefore a defining feature of age-related musculoskeletal disorders, and targeted elimination of these cells has emerged recently as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration of the skeleton and skeletal muscles. In this review, we summarize evidence of the role of senescent cells in the maintenance of bone homeostasis during childhood and their contribution to the pathogenesis of chronic musculoskeletal disorders, including osteoporosis, osteoarthritis, and sarcopenia. We highlight the diversity of the senescent cells in the microenvironment of bone, joint, and skeletal muscle tissue, as well as the mechanisms by which these senescent cells are involved in musculoskeletal diseases. In addition, we discuss how identifying and targeting senescent cells might positively affect pathologic progression and musculoskeletal system regeneration.
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影响因子：
64.8
作者：
Bartkova, Jirina;Rezaei, Nousin;Gorgoulis, Vassilis G.
通讯作者：
Gorgoulis, Vassilis G.
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
骨髓脂肪形成增加不会导致雌性小鼠年龄依赖性的阑尾骨质流失。
影响因子：
7.8
作者：
Almeida M;Kim HN;Han L;Zhou D;Thostenson J;Porter RM;Ambrogini E;Manolagas SC;Jilka RL
通讯作者：
Jilka RL
影响因子：
14.6
作者：
Berger, Claudie;Langsetmo, Lisa;Goltzman, David
通讯作者：
Goltzman, David
影响因子：
5.2
作者：
Alcalde-Estevez, Elena;Asenjo-Bueno, Ana;Lopez-Ongil, Susana
通讯作者：
Lopez-Ongil, Susana