Autoimmune hepatitis triggered by SARS-CoV-2 vaccination.
Autoimmune hepatitis triggered by SARS-CoV-2 vaccination.
复制标题
DOI：
10.1016/j.jaut.2021.102710
复制
发表时间：
2021-09
影响因子：
12.8
通讯作者：
Semmo N
中科院分区：
文献类型：
--
作者：
Vuille-Lessard É;Montani M;Bosch J;Semmo N
SARS冠状病毒2型（SARS-CoV-2）感染后可发生自身免疫性疾病。针对SARS-CoV-2的疫苗接种也可能引发自身免疫，正如其他疫苗所描述的那样。由分子模拟和旁观者激活诱导的异常免疫应答，特别是在易感个体中，是一种潜在的机制。我们报告了一例76岁女性桥本甲状腺炎和既往COVID-19感染，在SARS-CoV-2疫苗接种（mRNA-1273 SARS-CoV-2疫苗，Moderna®）后发生重度自身免疫性肝炎（典型特征包括强阳性抗平滑肌抗体和显著升高的免疫球蛋白G，以及典型的组织学发现）。SARS-CoV-2疫苗接种与自身免疫性疾病发展之间的联系需要进一步研究。虽然因果关系无法证明，但在接种已知自身免疫性疾病的个体时可能需要谨慎。
The development of autoimmune diseases has been reported after SARS-CoV-2 infection. Vaccination against SARS-CoV-2 could also trigger auto-immunity, as it has been described with other vaccines. An aberrant immune response induced by molecular mimicry and bystander activation, especially in predisposed individuals, is a potential mechanism. We report the case of a 76-year-old woman with Hashimoto thyroiditis and prior COVID-19 infection who developed severe autoimmune hepatitis (with typical features including strongly positive anti-smooth muscle antibody and markedly elevated immunoglobulins G, as well as typical histological findings) following SARS-CoV-2 vaccination (mRNA-1273 SARS-CoV-2 vaccine, Moderna®). The link between SARS-CoV-2 vaccination and the development of autoimmune diseases needs to be further investigated. Although a causality relationship cannot be proven, caution may be warranted when vaccinating individuals with known autoimmune diseases.