Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use - The Minnesota Heart Survey, 1980-1982 to 2000-2002
Twenty-year trends in serum cholesterol, hypercholesterolemia, and cholesterol medication use - The Minnesota Heart Survey, 1980-1982 to 2000-2002
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DOI：
10.1161/circulationaha.105.549857
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发表时间：
2005-12-20
期刊：
影响因子：
37.8
通讯作者：
Claas, SA
中科院分区：
文献类型：
--
作者：
Arnett, DK;Jacobs, DR;Claas, SA
背景 - 尽管美国胆固醇浓度有所下降，但大约 50% 的成年人的总胆固醇浓度 > 5.18 mmol/L，使他们处于患心脏病的“边缘高风险”。这种下降是否持续到21世纪还不得而知。我们根据明尼苏达州心脏调查 (MHS) 数据评估了胆固醇、高胆固醇血症、降脂药物使用以及胆固醇意识、治疗和控制的 20 年趋势。方法和结果 - 1980 年至 2002 年，在明尼阿波利斯 - 明尼苏达州圣保罗地区对 2500 至 5000 名成年人进行了五次独立、横断面、基于人口的调查。平均（非空腹）总胆固醇浓度持续经历了 20 年的衰退，期间夹杂着一段平静期。 2000年至2002年，经年龄调整的平均总胆固醇浓度，男性和女性分别为5.16和5.09 mmol/L（1980至1982年，男性和女性分别为5.49和5.38 mmol/L）。然而，所有年龄组的下降情况并不均匀。中年至老年人的胆固醇水平大幅下降，但年轻人总体变化不大，最近总胆固醇值有所上升。 2000年至2002年间，男性高胆固醇血症的平均患病率为54.9%，女性为46.5%，并且在研究期间两者均显着下降。 2000年至2002年，男性和女性经年龄调整的平均高密度脂蛋白胆固醇浓度分别为1.09和1.40 mmol/L，与之前的调查没有差异。 35 至 74 岁的男性和女性中，降脂药物的使用量均显着增加。对高胆固醇血症的认识、治疗和控制有所提高；然而，超过一半的处于边缘高风险的人仍然不知道自己的病情。 结论 - 尽管高胆固醇血症患病率持续下降，但相当一部分人群的胆固醇浓度仍然接近或处于增加风险的水平。
Background - Although US cholesterol concentrations have dropped, approximate to 50% of adults have total cholesterol concentrations > 5.18 mmol/L, putting them at "borderline-high risk" for heart disease. Whether the decline has continued into the 21st century is unknown. We assessed 20-year trends in cholesterol, hypercholesterolemia, lipid-lowering drug use, and cholesterol awareness, treatment, and control from Minnesota Heart Survey (MHS) data.Methods and Results - Five independent, cross-sectional, population-based surveys of 2500 to 5000 adults were conducted in the Minneapolis - St. Paul, Minn, area from 1980 to 2002. Mean (nonfasting) total cholesterol concentrations have continued a 20-year decline, punctuated by an intervening lull. Age-adjusted mean total cholesterol concentrations in 2000 to 2002 were 5.16 and 5.09 mmol/L for men and women, respectively ( in 1980 to 1982, 5.49 and 5.38 mmol/L for men and women, respectively) However, the decline has not been uniform across all age groups. Middle-aged to older people have shown substantial decreases, but younger people have shown little overall change and recently had increased total cholesterol values. The mean prevalence of hypercholesterolemia in 2000 to 2002 was 54.9% for men and 46.5% for women and has decreased significantly for both during the study. Age-adjusted mean high-density lipoprotein cholesterol concentrations in 2000 to 2002 were 1.09 and 1.40 mmol/L for men and women, respectively, and were not different from the prior survey. Lipid-lowering drug use rose significantly for both sexes aged 35 to 74 years. Awareness, treatment, and control of hypercholesterolemia have increased; however, more than half of those at borderline-high risk remain unaware of their condition.Conclusions - Although hypercholesterolemia prevalence continued to fall, significant population segments still have cholesterol concentrations near or at the level of increased risk.