EEG Asymmetry in Borderline Personality Disorder and Depression Following Rejection
EEG Asymmetry in Borderline Personality Disorder and Depression Following Rejection
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DOI：
10.1037/per0000032
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发表时间：
2014-04-01
影响因子：
2.8
通讯作者：
Hallquist, Michael N.
中科院分区：
文献类型：
--
作者：
Beeney, Joseph E.;Levy, Kenneth N.;Hallquist, Michael N.
边缘型人格障碍（BPD）和重性抑郁障碍（MDD）有许多共同的特征，包括烦躁情绪、易怒、自杀倾向和对人际排斥的高度敏感。然而，这些疾病与对排斥反应的不同反应有关：MDD患者更可能以退缩和孤立反应，而BPD患者似乎以增加的接近行为和更大的敌意反应。这些不同的反应模式背后的潜在机制尚未得到详细阐述。本研究的目的是评估是否前额叶皮质不对称与这些行为配置文件。在基线和BPD、MDD和健康对照（HC）个体参与拒绝任务后记录EEG α活动。虽然在基线时没有发现差异，但结果表明，在拒绝后，BPD患者表现出更大的左侧皮层激活，与接近动机一致，而MDD患者表现出更大的右侧皮层激活，与退缩动机一致。正如假设的那样，HC证明了更平衡的皮质轮廓。尽管BPD和MDD是高度共病的，容易混淆，并且在许多方面在现象学上相似，但患有这两种疾病的个体对感知到的拒绝的反应方式非常不同。
Borderline personality disorder (BPD) and major depressive disorder (MDD) share numerous features, including dysphoric affect, irritability, suicidality, and a heightened sensitivity to perceived interpersonal rejection. However, these disorders are associated with divergent profiles of reactivity to rejection: Individuals with MDD are more likely to respond with withdrawal and isolation, and those with BPD appear to respond with increased approach behaviors and greater hostility. Potential mechanisms underlying these divergent patterns of response have not been elaborated. The goal of the present study was to assess whether prefrontal cortical asymmetry is associated with these behavioral profiles. EEG alpha activity was recorded at baseline and after individuals with BPD, MDD and healthy controls (HCs) participated in a rejection task. Although no differences were found at baseline, results demonstrated that following rejection, individuals with BPD showed greater left cortical activation, consistent with approach motivation, whereas those with MDD showed greater right cortical activation, consistent with withdrawal motivation. HCs evidenced a more balanced cortical profile, as hypothesized. Although BPD and MDD are highly comorbid, are easily confused, and are phenomenologically similar in a number of ways, individuals with these two disorders respond in very different ways to perceived rejection.