Current Bioengineering Methods for Whole Kidney Regeneration.
Current Bioengineering Methods for Whole Kidney Regeneration.
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DOI：
10.1155/2015/724047
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发表时间：
2015
影响因子：
4.3
通讯作者：
Yokoo T
中科院分区：
文献类型：
--
作者：
Yamanaka S;Yokoo T
肾脏再生可能为无免疫抑制移植提供取之不尽的组织和器官来源。目前，它正在引起相当大的关注，并可能取代肾透析作为肾功能衰竭的最终治疗策略。然而，解剖并发症使肾脏再生困难。在这里，我们回顾了肾脏再生领域的最新进展，包括：(i)诱导多能干细胞/胚胎干细胞定向分化为肾细胞；囊胚失补；（iii）使用去细胞尸体支架；（四）胚胎器官移植；(5)利用肾源生态位培养异种胚胎，用于干细胞肾再生。所有这些方法都代表了治疗慢性肾脏疾病患者的潜在有前途的治疗策略。尽管肾脏再生仍然存在许多障碍，但我们希望创新的策略和可靠的研究将最终使终末期肾病患者的肾功能恢复。
Kidney regeneration is likely to provide an inexhaustible source of tissues and organs for immunosuppression-free transplantation. It is currently garnering considerable attention and might replace kidney dialysis as the ultimate therapeutic strategy for renal failure. However, anatomical complications make kidney regeneration difficult. Here, we review recent advances in the field of kidney regeneration, including (i) the directed differentiation of induced pluripotent stem cells/embryonic stem cells into kidney cells; (ii) blastocyst decomplementation; (iii) use of a decellularized cadaveric scaffold; (iv) embryonic organ transplantation; and (v) use of a nephrogenic niche for growing xenoembryos for de novo kidney regeneration from stem cells. All these approaches represent potentially promising therapeutic strategies for the treatment of patients with chronic kidney disease. Although many obstacles to kidney regeneration remain, we hope that innovative strategies and reliable research will ultimately allow the restoration of renal function in patients with end-stage kidney disease.
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