Body Mass Index From Early to Late Childhood and Cardiometabolic Measurements at 11 to 12 Years
Body Mass Index From Early to Late Childhood and Cardiometabolic Measurements at 11 to 12 Years
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DOI：
10.1542/peds.2019-3666
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发表时间：
2020-08-01
期刊：
影响因子：
8
通讯作者：
Wake, Melissa
中科院分区：
文献类型：
--
作者：
Lycett, Kate;Juonala, Markus;Wake, Melissa
在基于人群的样本中，我们研究了特定年龄的超重和/或肥胖以及整个儿童期的总体BMI增长模式如何预测11至12岁的心脏代谢表型。目的：研究特定年龄段的超重和肥胖以及整个儿童期的总体BMI增长模式如何预测11 - 12岁时的心脏代谢表型。方法：在一个以人群为基础的5107名婴儿样本中，在2 - 3岁和10 - 11岁之间每2年测量一次BMI。我们使用生长曲线模型确定了5种BMI轨迹。在11 - 12岁时，1811名儿童完成了代谢综合征风险评分、颈动脉-股动脉脉搏波速度和颈动脉内中膜厚度的评估。多变量回归模型被用来估计协会，调整潜在的混杂因素（如，年龄，性别，吸烟暴露，小于胎龄）。结果：超重和肥胖，从幼儿期开始，在11至12岁的心脏代谢风险较高。在6至7岁时，与健康体重的儿童相比，超重儿童的代谢综合征风险评分高出0.23 SD单位（95%置信区间0.05 - 0.41），肥胖儿童高出0.76 SD单位（0.51-1.01），10至11岁的相关性几乎翻了一番。肥胖（但不超重）儿童在6 - 7岁时脉搏波速度（0.64-0.73 SD单位）较高，在所有年龄段颈动脉内膜中层厚度（0.20-0.30 SD单位）略高。累积暴露于高体重指数从2至3岁进行最大的心脏代谢风险，与跨trajectors.CONCLUSIONS梯度的风险：高早期儿童体重指数已经默默地与发展的心脏代谢风险的11至12年，突出了迫切需要采取有效的行动，以减少超重和肥胖的儿童早期。
In a population-based sample, we examine how overweight and/or obesity at specific ages and overall BMI growth patterns throughout childhood predict cardiometabolic phenotypes at age 11 to 12 years. OBJECTIVES:To examine how overweight and obesity at specific ages and overall BMI growth patterns throughout childhood predict cardiometabolic phenotypes at 11 to 12 years.METHODS:In a population-based sample of 5107 infants, BMI was measured every 2 years between ages 2 to 3 and 10 to 11 years. We identified 5 BMI trajectories using growth curve models. At ages 11 to 12 years, 1811 children completed assessments for metabolic syndrome risk scores, carotid-femoral pulse wave velocity, and carotid intima-media thickness. Multivariable regression models were used to estimate associations, adjusted for potential confounders (eg, age, sex, smoking exposure, and small for gestational age).RESULTS:Overweight and obesity from early childhood onward were strongly associated with higher cardiometabolic risk at 11 to 12 years of age. At age 6 to 7 years, compared with those with a healthy weight, children with overweight had higher metabolic syndrome risk scores by 0.23 SD units (95% confidence interval 0.05 to 0.41) and with obesity by 0.76 SD units (0.51-1.01), with associations almost doubling by age 10 to 11 years. Obese (but not overweight) children had higher outcome pulse wave velocity (0.64-0.73 SD units) from ages 6 to 7 years and slightly higher outcome carotid intima-media thickness (0.20-0.30 SD units) at all ages. Cumulative exposure to high BMI from 2 to 3 years of age carried the greatest cardiometabolic risk, with a gradient of risk across trajectories.CONCLUSIONS:High early-childhood BMI is already silently associated with the development of cardiometabolic risk by 11 to 12 years, highlighting the urgent need for effective action to reduce overweight and obesity in early childhood.