Coordinated accumbal dopamine release and neural activity drive goal-directed behavior
Coordinated accumbal dopamine release and neural activity drive goal-directed behavior
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DOI：
10.1016/j.neuron.2007.03.021
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发表时间：
2007-04-19
期刊：
影响因子：
16.2
通讯作者：
Wightman, R. Mark
中科院分区：
文献类型：
--
作者：
Cheer, Joseph F.;Aragona, Brandon J.;Wightman, R. Mark
颅内自我刺激（ICSS）激活介导奖赏的神经通路，包括多巴胺能终末区，如丘脑核（NAc）。然而，多巴胺在ICSS介导的奖励中的直接作用受到质疑。在这里，同时伏安和电生理记录从同一个电极显示，在某些网站，预期的多巴胺浪涌和变化的神经元放电模式在ICSS的发病是一致的，而网站缺乏多巴胺的变化也缺乏模式化的发射。壳内微输注D1而非D2受体拮抗剂可阻断ICSS。一种离子电渗疗法的方法来探讨多巴胺拮抗剂对放电模式的影响，而不改变行为。与微量输注实验类似，ICSS相关的放电在D1受体阻断后选择性减弱。这项工作建立了预期的上升多巴胺和发射模式之间的时间联系，在NAC壳ICSS，并建议他们可能发挥类似的作用，自然奖励和药物自我管理。
Intracranial self-stimulation (ICSS) activates the neural pathways that mediate reward, including dopaminergic terminal areas such as the nucleus accumbens (NAc). However, a direct role of dopamine in ICSS-mediated reward has been questioned. Here, simultaneous voltammetric and electrophysiological recordings from the same electrode reveal that, at certain sites, the onset of anticipatory dopamine surges and changes in neuronal firing patterns during ICSS are coincident, whereas sites lacking dopamine changes also lack patterned firing. Intrashell microinfusion of a D1, but not a D2 receptor antagonist, blocks ICSS. An iontophoresis approach was implemented to explore the effect of dopamine antagonists on firing patterns without altering behavior. Similar to the microinfusion experiments, ICSS-related firing is selectively attenuated following D1 receptor blockade. This work establishes a temporal link between anticipatory rises of dopamine and firing patterns in the NAc shell during ICSS and suggests that they may play a similar role with natural rewards and during drug self-ad ministration.