The Expression of MAS1, an Angiotensin (1-7) Receptor, in the Eutopic Proliferative Endometria of Endometriosis Patients
The Expression of MAS1, an Angiotensin (1-7) Receptor, in the Eutopic Proliferative Endometria of Endometriosis Patients
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DOI：
10.1159/000490561
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发表时间：
2018-01-01
影响因子：
2.1
通讯作者：
Kawana, Kei
中科院分区：
文献类型：
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作者：
Nakajima, Takahiro;Chishima, Fumihisa;Kawana, Kei
背景/目的：我们证明 AT1 和 AT2 在子宫内膜异位症中均有表达，并且这两种途径均可平衡肾素-血管紧张素系统。 MAS1 是血管紧张素 (1-7) 的一种特异性受体，可对抗 AT1 通路相关的组织重塑。 MAS1 是否对子宫内膜异位症的发病机制有影响尚不清楚。材料和方法：从 29 例子宫内膜囊肿患者中获取卵巢子宫内膜异位组织 (endo-Ov) 和在位子宫内膜组织 (endo-Em)。正常子宫内膜组织（cont-Em）取自无子宫内膜异位症的患者。对子宫内膜异位症相关组织中的 MAS1、AT1 和 AT2 进行免疫组织化学染色。通过定量逆转录 PCR 检查这些受体的 mRNA 水平。结果：子宫内膜异位病灶腺上皮根尖侧MAS1免疫阳性。无论月经周期阶段如何，endo-Ov 中的 MAS1 mRNA 水平均显着增加。子宫内膜异位症患者增殖组织中的 MAS1 mRNA 水平显着高于对照组。与对照组相比，子宫内膜异位症患者增殖组织中MAS1与AT1 mRNA的比率主要升高。结论：子宫内膜中MAS1的高表达可能通过增殖组织的迁移促进子宫内膜异位症的发生。 (c) 2018 S. Karger AG，巴塞尔
Background/Aim: We demonstrated that AT1 and AT2 are expressed and both pathways balance the renin-angiotensin system in endometriosis. MAS1, a specific receptor of angiotensin (1-7), opposes AT1 pathway-associated tissue remodelling. It is not known whether MAS1 has an effect on the pathogenesis of endometriosis or not. Materials and Methods: Ovarian endometriotic tissues (endo-Ov) and eutopic endometrial tissues (endo-Em) were obtained from 29 patients with endometrial cysts. Normal endometrial tissues (cont-Em) were obtained from patients without endometriosis. Immunohistochemical staining was performed for MAS1, AT1 and AT2 in the endometriosis-associated tissues. The mRNA levels of these receptors were examined by quantitative reverse transcription PCR. Results: MAS1 was immunepositive at the apical side of the glandular epithelium in the endometriotic lesions. The MAS1 mRNA levels in endo-Ov were increased significantly, irrespective of the menstrual cycle phase. The MAS1 mRNA levels were significantly higher in the proliferative-tissues of the endometriosis patients than in those of the controls. The ratio of the MAS1 to the AT1 mRNA in the proliferative tissues was increased predominantly in the endometriosis patients compared with that in the controls. Conclusion: High MAS1 expression in the endometrium might promote the initiation of endometriosis via migration of proliferative tissue. (c) 2018 S. Karger AG, Basel