Ovarian Cancer Risk in Relation to Blood Cholesterol and Triglycerides.
Ovarian Cancer Risk in Relation to Blood Cholesterol and Triglycerides.
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DOI：
10.1158/1055-9965.epi-21-0443
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Tworoger SS
中科院分区：
文献类型：
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作者：
Trabert B;Hathaway CA;Rice MS;Rimm EB;Sluss PM;Terry KL;Zeleznik OA;Tworoger SS
The association between circulating cholesterol and triglyceride levels and ovarian cancer risk remains unclear. We prospectively evaluated the association between cholesterol (total, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C)) and triglycerides and ovarian cancer incidence in a case-control study nested in the Nurses’ Health Study (NHS) and NHSII cohorts and a longitudinal analysis in the UK Biobank. A total of 290 epithelial ovarian cancer cases in the NHS/NHSII and 551 cases in UK Biobank were diagnosed after blood collection. We observed a reduced ovarian cancer risk comparing the top to bottom quartile of total cholesterol (meta-analysis RR [95%CI]: 0.81 [0.65–1.01], p-trend 0.06), with no heterogeneity across studies (p-heterogeneity=0.74). Overall, no clear patterns were observed for HDL-C, LDL-C, or triglycerides and ovarian cancer risk. Comparing triglyceride levels at clinically relevant cutpoints (>200 vs. ≤200 mg/dL) for cases diagnosed more than 2 years after blood draw saw a positive relationship with risk (1.57 [1.03–2.42]; p-heterogeneity=0.003). Results were similar by serous/non-serous histotype, menopausal status/hormone use, and body mass index. Data from two large cohorts in the US and UK suggest that total cholesterol levels may be inversely associated with ovarian cancer risk, while triglycerides may be positively associated with risk when assessed at least 2 years before diagnosis; albeit both associations were modest. This analysis of two large prospective studies suggests that circulating lipid levels are not strongly associated with ovarian cancer risk. The positive triglyceride-ovarian cancer association warrants further evaluation.
