Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum
Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum
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DOI：
10.1080/10286020.2018.1551372
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发表时间：
2019-09-02
影响因子：
1.7
通讯作者：
Dai, Jun-Gui
中科院分区：
文献类型：
--
作者：
Feng, Jia-Min;Li, Min;Dai, Jun-Gui
从水苏（Stachybotrysum chartarum）中分离得到3个新的苯基螺吡喃衍生物，分别命名为水苏素H和I（1和2），水苏素E（3），以及一个已知化合物水苏内酰胺（4）。通过大量的NMR数据和质谱分析确定了它们的结构。化合物1和2显示对钾通道Kv1.3的抑制作用，IC 50值分别为13.4和10.9 μ M。
Three new phenylspirodrimanes derivatives named stachybotrysins H and I (1 and 2) and stachybotrin E (3), together with one known compound stachybotrylactam (4), were isolated from Stachybotrys chartarum CGMCC 3.5365. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 1 and 2 showed inhibitory effect towards potassium channel Kv1.3 with IC50 values of 13.4 and 10.9 mu M, respectively.