Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
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DOI：
10.1016/j.jalz.2019.03.016
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发表时间：
2019-07-01
影响因子：
14
通讯作者：
Murray, Melissa E.
中科院分区：
文献类型：
--
作者：
Lowe, Val J.;Lundt, Emily S.;Murray, Melissa E.
简介：神经影像学生物标志物是重要的早期诊断阿尔茨海默氏病，比较多模态神经影像尸检data.Methods：我们比较了病理结果从前瞻性尸检队列（n = 100）匹兹堡化合物B PET（PiB-PET），F-18-氟脱氧葡萄糖PET（FDG-PET），MRI。神经影像学生物标志物和神经病理schemes.Results之间的相关性：PiB-PET表现出很强的相关性与塔尔淀粉样蛋白阶段和联盟建立登记阿尔茨海默氏病评分和归类44%的塔尔阶段1参与者为阳性。FDG-PET和MRI与Alzheimer型病理学中Braak缠结分期适度相关。一部分神经炎斑块评分为“无”或“稀疏”的参与者由于弥漫性淀粉样斑块而具有升高的PiB-PET信号。参与者的结果特征为“可疑的非阿尔茨海默氏病的病理生理学”代表15%的group.Discussion：PiB-PET与阿尔茨海默氏病，神经炎性斑块，弥漫性斑块。FDG-PET和MRI与神经病理学方案有适度的相关性。具有被表征为疑似非阿尔茨海默病病理生理学的结果的参与者最常患有原发性年龄相关性tau蛋白病。(C)2019年，阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Introduction: Neuroimaging biomarkers are important for early diagnosis of Alzheimer's disease, and comparing multimodality neuroimaging to autopsy data is essential.Methods: We compared the pathologic findings from a prospective autopsy cohort (n = 100) to Pittsburgh compound B PET (PiB-PET), F-18-fluorodeoxyglucose PET (FDG-PET), and MRI. Correlations between neuroimaging biomarkers and neuropathologic schemes were assessed.Results: PiB-PET showed strong correlations with Thal amyloid phase and Consortium to Establish a Registry for Alzheimer's Disease score and categorized 44% of Thal phase 1 participants as positive. FDG-PET and MRI correlated modestly with Braak tangle stage in Alzheimer's type pathology. A subset of participants with "none" or "sparse" neuritic plaque scores had elevated PiB-PET signal due to diffuse amyloid plaque. Participants with findings characterized as "suspected non-Alzheimer's pathophysiology" represented 15% of the group.Discussion: PiB-PET is associated with Alzheimer's disease, neuritic plaques, and diffuse plaques. FDG-PET and MRI have modest correlation with neuropathologic schemes. Participants with findings characterized as suspected non-Alzheimer's pathophysiology most commonly had primary age-related tauopathy. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.