Patterning function of homothorax/extradenticle in the thorax of Drosophila
Patterning function of homothorax/extradenticle in the thorax of Drosophila
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DOI：
10.1242/dev.01585
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发表时间：
2005-02-01
期刊：
影响因子：
4.6
通讯作者：
Azpiazu, N
中科院分区：
文献类型：
--
作者：
Aldaz, S;Morata, G;Azpiazu, N
在果蝇中，形态多样性是通过激活不同身体亚区中不同的活跃发育调控基因而产生的。在这里，我们研究了同胸/牙外环(hth/exd)基因对在前间胸(NOTOM)模式形成中的作用。这两个基因在相同的区域活跃，作为一个单一的功能单位。我们发现它们最初在鼻甲中的统一表达在发育过程中被下调，并被限制在两个不同的亚域，即α和β亚区。这种调制似乎对在两个亚域中形成不同的模式很重要。Hth/exd的表达调控是通过Pax基因EYG(EYG)和DPP途径的联合抑制作用实现的。HTH/EXD在EYG活跃的体部区域被抑制，也包含高水平的DPP活性。我们还提出了HTH和EYG蛋白之间的分子相互作用的证据，这可能对阿尔法亚域的模式形成很重要。
In Drosophila, the morphological diversity is generated by the activation of different sets of active developmental regulatory genes in the different body subdomains. Here, we have investigated the role of the homothorax/extradenticle (hth/exd) gene pair in the elaboration of the pattern of the anterior mesothorax (notum). These two genes are active in the same regions and behave as a single functional unit. We find that their original uniform expression in the notum is downregulated during development and becomes restricted to two distinct, alpha and beta subdomains. This modulation appears to be important for the formation of distinct patterns in the two subdomains. The regulation of hth/exd expression is achieved by the combined repressing functions of the Pax gene eyegone (eyg) and of the Dpp pathway. hth/exd is repressed in the body regions where eyg is active and that also contain high levels of Dpp activity. We also present evidence for a molecular interaction between the Hth and the Eyg proteins that may be important for the patterning of the alpha subdomain.