Isolation of aggresomes and other large aggregates.
Isolation of aggresomes and other large aggregates.
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DOI：
10.1002/0471143030.cb0338s48
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发表时间：
2010-09
影响因子：
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通讯作者：
Sherman, Michael Y
中科院分区：
文献类型：
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作者：
Meriin, Anatoli B;Wang, Yan;Sherman, Michael Y
Upon permanent stresses and in various diseases, small protein aggregates may accumulate in cells and cause toxicity. A recently discovered protective system transports these aggregates to the centrosome location via microtubules, to form a large agglomerate of aggregates called the aggresome. Here, we describe a newly developed method for isolating aggresomes. This principle can also be used for purification of other large structures and even organelles.Curr. Protoc. Cell Biol. 48:3.38.1‐3.38.9. © 2010 by John Wiley & Sons, Inc.
