Cell cycle regulation by MicroRNAs in embryonic stem cells.
Cell cycle regulation by MicroRNAs in embryonic stem cells.
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DOI：
10.1158/0008-5472.can-09-0309
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发表时间：
2009-05-15
期刊：
影响因子：
11.2
通讯作者：
Blelloch R
中科院分区：
文献类型：
--
作者：
Wang Y;Blelloch R
细胞周期在正常发育过程中是紧密协调的。胚胎干细胞（ES）具有独特的细胞周期结构，其中G1/S限制在很大程度上不存在，使细胞能够快速通过G1期并进入S期。这种加速的细胞周期允许早期胚胎快速生长。最近的实验表明，小的非编码RNA，microRNA，在实现这种独特的细胞周期结构中发挥着核心作用。负责的microRNA通过抑制G1/S转换的多种抑制剂发挥作用。随着ES细胞分化和G1期延长，这些miRNA的表达急剧下降。一些相同的miRNA在癌症中过表达，它们可以促进肿瘤生长，这表明在ES细胞和癌症中miRNA调节细胞周期控制的共同机制。这篇综述讨论了这些最新的研究结果的背景下，更广泛的知识细胞周期控制在正常和异常的发展。
The cell cycle is tightly orchestrated during normal development. Embryonic stem (ES) cells have a unique cell cycle structure, where the G1/S restriction is largely absent enabling cells to rapidly move through G1 and enter S phase. This hastened cell cycle allows the early embryo to rapidly grow. Recent experiments suggest that small non-coding RNAs, the microRNAs, play a central role in achieving this unique cell cycle structure. The responsible microRNAs function by suppressing multiple inhibitors of the G1/S transition. Expression of these miRNAs drops dramatically as the ES cells differentiate and the G1 phase extends. Some of the same miRNAs are overexpressed in cancers where they can promote tumor growth suggesting common mechanisms of miRNA regulated cell cycle control in ES cells and cancers. This review discusses these recent findings in the context of broader knowledge of cell cycle control in normal and abnormal development.