An experimental model simulating local recurrence and pelvic lymph node metastasis following orthotopic induction of prostate cancer.
An experimental model simulating local recurrence and pelvic lymph node metastasis following orthotopic induction of prostate cancer.
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模拟前列腺癌原位诱导后局部复发和盆腔淋巴结转移的实验模型。
DOI：
10.1002/pros.2990240604
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Fair,WR
中科院分区：
文献类型：
--
作者：
Vieweg,J;Heston,WD;Gilboa,E;Fair,WR
为了建立一种更接近人类前列腺癌的器官环境和转移途径的动物模型，采用哥本哈根大鼠前列腺癌腹叶原位移植的方法建立了R3327-MatLyLu肿瘤模型。这一手术可重复地导致前列腺癌转移到盆腔和腹膜后淋巴结，而且总是转移到肺部。此外，采用原位肿瘤植入和随后的手术切除原发肿瘤相结合的方法建立了肿瘤复发模型。当诱导后4天或更长时间行前列腺切除术时，所有动物的肿瘤均局部复发。所描述的手术程序可能提供一种动物模型来测试晚期前列腺癌对实验性辅助治疗方案的体内反应。在原位建立的R3327-MatLyLu肿瘤中，使用细胞因子基因修饰的前列腺肿瘤细胞作为细胞抗肿瘤疫苗的免疫学研究正在进行中。©1994 Wiley-Liss，Inc.
In order to develop an animal model that more closely simulates the organ environment and metastatic routes of human prostatic cancer, R3327‐MatLyLu tumors were induced by orthotopic implantation in the ventral prostatic lobe of Copenhagen rats. This procedure reproducibly resulted in metastatic spread of the intraprostatic tumor to the pelvic and retroperitoneal lymph nodes, and invariably to the lungs. Further, a tumor recurrence model was established using an approach that combined orthotopic tumor implantation and subsequent surgical resection of the primary tumor. When prostatectomy was carried out 4 days or more after induction, tumors recurred locally in all animals. The surgical procedures described may provide an animal model to test the in vivo response to experimental adjuvant treatment protocols for advanced prostate cancer. Immunological studies are now in progress using cytokine gene‐modified prostatic tumor cells as cellular antitumor vaccines in orthotopically established R3327‐MatLyLu tumors. © 1994 Wiley‐Liss, Inc.