Changes in intestinal microflora in digestive tract diseases during pregnancy
Changes in intestinal microflora in digestive tract diseases during pregnancy
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妊娠期消化道疾病中肠道菌群的变化
DOI：
10.1007/s00404-019-05336-0
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发表时间：
2019-11-27
影响因子：
2.6
通讯作者：
Li, Yanqing
中科院分区：
文献类型：
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作者：
Jin, Min;Li, Dong;Li, Yanqing
目的研究妊娠合并消化系统疾病孕妇肠道菌群组成，分析其与妊娠合并消化系统疾病的关系。方法对71例孕妇[急性脂肪肝6例，便秘21例，过度呕吐24例，正常妊娠20例]和26例非妊娠妇女(NP组)的肠道微生物区系组成进行了16条S核糖核酸序列测定。结果与CP组相比，消化系统疾病(AF、C、V)组肠道菌群的相对丰度显著增加，而Terrisporter、Dysonomonas、Adlercreutzia、Fusicatenisis、Blautia等5个常见属的相对丰度均有所下降。在消化系统疾病(AF、C、V)组中，卡诺杆菌、嗜冷杆菌、嗜冷杆菌等13个常见属的丰度高于NP组，而Blautias、Terrisporbacter等27个常见属的丰度低于NP组。AF组和C组之间有69个属的差异，AF组和V组之间有2个属，C组和V组之间有63个属。结论不动杆菌、肠球菌、拟青霉、布鲁氏菌和胶状杆菌的丰富可能与妊娠期消化系统疾病有关。这些发现进一步支持了这样的想法，即以肠道微生物区系为靶点可能是改善妊娠期间消化系统疾病的一种新的预防或治疗方法。
PurposeThis study aimed to investigate the gut microbiome composition in pregnant women with digestive diseases to analyze the relationships between the microflora changes and digestive diseases during pregnancy.MethodsFecal samples obtained from 71 pregnant women [six acute fatty liver (AF group), 21 constipation (C group), 24 excessive vomiting (V group) and 20 normal pregnancy (CP group)] and 26 non-pregnant (NP group) women were subjected to 16 s rRNA sequencing. Differential analysis of intestinal flora at the genera level was performed.ResultsThe relative abundance ofCoprobacillus,Acinetobacter,Enterococcus,WeissellaandLysinibacilluswas increased in the digestive diseases (AF, C and V) groups compared with CP group, whereas that of five common genera, includingTerrisporobacter,Dysgonomonas,Adlercreutzia,FusicatenibacterandBlautia, was decreased in digestive diseases groups. Additionally, in digestive diseases (AF, C and V) groups, the abundance of 13 common genera, such asCarnobacterium,CoprobacillusandPsychrobacter, was higher than NP group, whereas that of 27 common genera, such asBlautiaandTerrisporobacter, was lower than NP group. About 69 genera were differentially abundant between AF and C groups; two genera (AerococcusandSenegalimassilia) were identified between AF and V groups; moreover, total 63 genera were obtained between C and V groups.ConclusionOur data revealed that the abundance ofAcinetobacter,Enterococci,Paenibacillus,BlautiaandCollinsellamight be associated with the digestive diseases during pregnancy. These findings further supported the idea that targeting the gut microbiota could be a new prevention or therapeutic approach for improving digestive diseases during pregnancy.